469-83-0

469-83-0 structure

Name: Cafestol
Chemical Name: cafestol
CAS Number: 469-83-0
Molecular Formula: C₂₀H₂₈O₃
Molecular Weight: 316.435
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2018-07-08 12:51:38
Modify Date: 2026-07-03 10:27:33
Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects[1].

Name	cafestol
Synonyms	CAFESTOL 5A,8-Methano-5ah-cyclohta(5,6)naphtho(2,1-B)furan-7-methanol, 3B,4,5,6,7,8,9,10,10A,10B,11,12-dodecahydro-7-hydroxy-10B-methyl-, (3bs,5as,7R,8R,10,10bs) Ccris CAFESTEROL CAFESTOL(SH) 3bα,4,5,6,7,8,9,10,10aα,10b,11,12-Dodecahydro-7β-hydroxy-10bβ-methyl-5aβ,8β-methano-5aH-cyclohta[5,6]naphtho[2,1-b]furan-7α-methanol (3bS,5aS,7R,8R,10,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohta[5,6]naphtho[2,1-b]furan-7-methanol Cafestol-RM (1S,4S,12S,13R,16R,17R)-17-(Hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.0.0.0]nonadeca-5(9),6-dien-17-ol unii-ac465t6q6w 5A,8-Methano-5ah-cyclohta(5,6)naphtho(2,1-B)furan-7-methanol, 3B,4,5,6,7,8,9,10,10A,10B,11,12-dodecahydro-7-hydroxy-10B-methyl-, (3bs-(3balpha,5abeta,7beta,8beta,10aalpha,10bbeta)) (1S,4S,12S,13R,16R,17R)-17-(hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.01,13.0,12.0,]nonadeca-5,6-dien-17-ol

Description	Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> PGE synthase Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK COX-2 NF-κB
References	[1]. Shen T, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32.

Density	1.2±0.1 g/cm3
Boiling Point	468.6±45.0 °C at 760 mmHg
Melting Point	160-162ºC (with decomposition) (ethyl ether pentane )
Molecular Formula	C₂₀H₂₈O₃
Molecular Weight	316.435
Flash Point	237.2±28.7 °C
Exact Mass	316.203857
PSA	53.60000
LogP	4.03
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.604