Cafestol

Modify Date: 2024-01-02 07:24:17

Cafestol structure	Common Name	Cafestol
	CAS Number	469-83-0	Molecular Weight	316.435
	Density	1.2±0.1 g/cm3	Boiling Point	468.6±45.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₈O₃	Melting Point	160-162ºC (with decomposition) (ethyl ether pentane )
	MSDS	N/A	Flash Point	237.2±28.7 °C

Use of Cafestol

Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects[1].

Name	cafestol
Synonym	More Synonyms

Description	Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> PGE synthase Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK COX-2 NF-κB
References	[1]. Shen T, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32.

Density	1.2±0.1 g/cm3
Boiling Point	468.6±45.0 °C at 760 mmHg
Melting Point	160-162ºC (with decomposition) (ethyl ether pentane )
Molecular Formula	C₂₀H₂₈O₃
Molecular Weight	316.435
Flash Point	237.2±28.7 °C
Exact Mass	316.203857
PSA	53.60000
LogP	4.03
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.604

(1S,4S,12S,13R,16R,17R)-17-(Hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.0.0.0]nonadeca-5(9),6-dien-17-ol

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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Cafestol
Price: ￥1478.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Cafestol
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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