348622-88-8

348622-88-8 structure

Name: UK 383367
Chemical Name: 5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide
CAS Number: 348622-88-8
Molecular Formula: C₁₅H₂₄N₄O₄
Molecular Weight: 324.375
Catalog: Biochemical Inhibitor Metabolism Procollagen C Proteinase Inhibitor
Create Date: 2016-09-25 17:20:00
Modify Date: 2024-01-02 17:28:59
UK-383367 (UK 383367) is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase) with IC50 of 44 nM; Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).IC50 value: 44 nMTarget: procollagen C-proteinaseUK-383367 (UK 383367) is useful for anti-scarring agent

Name	5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide
Synonyms	CS-0414 UK383367 1,2,4-Oxadiazole-5-propanamide, 3-(aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-, (βR)- S2224_Selleck 5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide UK 383367 5-[(3R)-6-Cyclohexyl-1-(hydroxyamino)-1-oxo-3-hexanyl]-1,2,4-oxadiazole-3-carboxamide UK-383367

Description	UK-383367 (UK 383367) is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase) with IC50 of 44 nM; Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).IC50 value: 44 nMTarget: procollagen C-proteinaseUK-383367 (UK 383367) is useful for anti-scarring agent
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Procollagen C Proteinase Research Areas >> Others
References	[1]. Allan GA, Gedge JI, Nedderman AN, Roffey SJ, Small HF, Webster R.Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity.Xenobiotica. 2006 May;36(5):399-418. [2]. Bailey et al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 18 6562.