Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Hemin
Price: ￥178.0/5g ￥608.0/25g
Purity: 98.0%
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Contact: Liu jia

DC Chemicals Limited
China
Product Name: Hemin
Price: $Inquiry/25mg $Inquiry/50mg $Inquiry/250mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Hemin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Hemin
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM - Hemin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

16009-13-5

16009-13-5 structure

16009-13-5 structure

Name: Hemin
Chemical Name: hemin
CAS Number: 16009-13-5
Molecular Formula: C₃₄H₃₂ClFeN₄O₄
Molecular Weight: 651.940
Catalog: Food additive Nutrition supplements Inorganic salts
Create Date: 2018-02-07 08:00:00
Modify Date: 2024-01-02 12:25:39
Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO)-1 inducer.

Name	hemin
Synonyms	Iron, chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(2-)-κN,κN]- Hemin Chloro(protoporphyrinato)iron(III) MFCD00010726 Chloro[3,3'-(3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphyrindiyl-κN,N)dipropanoato(2-)]iron Ferriprotoporphyrin chloride 7,12-Diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid Ferriheme chloride Ferriprotoporphyrin IX chloride Chloroprotoporphyrin IX iron(III) EINECS 240-140-1

Description	Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO)-1 inducer.
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Target	Heme oxygenase[1]
In Vitro	Hemin and PGJ2, used as positive controls, strongly increase both expression and activity of HMOX after 4 and 12 h, respectively. Indeed, a significant effect is found of 30 μM Hemin on cell proliferation in all used cell lines after 48 h, which is dose-dependent. Hemin treatment decreases cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons. Furthermore, enhancement of anti-proliferative effects of statins is observed by Hemin, documented as decreased cell proliferation after 48 h of co-treatment[1].
In Vivo	Following the i.p. administration of Hemin (100 μmol/kg), the HO-1 level in the renal cortex begins to increase gradually. The HO-1 level reaches its peak 24 h after Hemin preconditioning. HO-1 is expressed mainly in the renal tubules. The HO-2 level in the kidney does not change following Hemin preconditioning[2].
Cell Assay	For the cell proliferation assay, cells are seeded into 96 well (5-12.5×104 cells per mL according to the cell line) and kept at 37°C and 5 % CO2. After 24 h, cells are treated with statins or/and Hemin, followed by the MTT test as a general cell proliferation assay[1].
Animal Admin	Mice[2] Eight- to ten-week-old male BABL/c mice are used for the ischemia-reperfusion (I/R) experiments. The animals are divided into five groups as follows: (1) the sham group undergo isolation of the bilateral renal arteries without clamping; (2) the vehicle group receive an intraperitoneal (i.p.) injection of 4 mL/kg PBS as a vehicle control (with IRI); (3) the Hemin-preconditioned group receive Hemin, a potent inducer of HO-1, at 100 μmol/kg i.p.; (4) the Hemin plus ZnPP group receive zinc protoporphyrin IX, an inhibitor of HO-1 activity, at 5 mg/kg i.p. 6 h after receiving 100 μmol/kg Hemin i.p.; and (5) the Hemin plus PD98059 group receive PD98059, an inhibitor of ERK1/2 activity, at 10 mg/kg i.p. 6 h after receiving 100 μmol/kg Hemin i.p. Both inhibitors are administered i.p. 2 h before I/R, whereas Hemin was administered 8 h before I/R.
References	[1]. Vanova K, et al. Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells. BMC Cancer. 2016 May 12;16:309. [2]. Chen HH, et al. Heme oxygenase-1 ameliorates kidney ischemia-reperfusion injury in mice through extracellular signal-regulated kinase 1/2-enhanced tubular epithelium proliferation. Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2195-201.

Melting Point	300 °C
Molecular Formula	C₃₄H₃₂ClFeN₄O₄
Molecular Weight	651.940
Exact Mass	651.146179
PSA	109.18000
LogP	4.29920
Storage condition	2-8°C
Stability	Stable. Incompatible with strong oxidizing agents. Combustible.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	N,Xi
Risk Phrases	R10:Flammable. R19:May form explosive peroxides. R50:Very Toxic to aquatic organisms. R36:Irritating to the eyes.
Safety Phrases	24/25-22-36-26
RIDADR	UN 3272 3/PG 3
WGK Germany	3
RTECS	LJ8080000
Packaging Group	III
Hazard Class	3