16009-13-5
16009-13-5 structure
- Name: Hemin
- Chemical Name: hemin
- CAS Number: 16009-13-5
- Molecular Formula: C34H32ClFeN4O4
- Molecular Weight: 651.940
- Catalog: Food additive Nutrition supplements Inorganic salts
- Create Date: 2018-02-07 08:00:00
- Modify Date: 2026-07-02 10:18:40
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Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO)-1 inducer.
| Name | hemin |
|---|---|
| Synonyms |
chlorido(protoporphyrinato)iron(III)
HEMIN HEMIN, BOVINE MOLECULBIOLOGY ADE Ferriprotoporphyrine IV Cloride Hemin from Bovine Chlorohemin, Bovine Chlorohemin Chloroprotoporphyrin IX iron(III) HEMIN BOVINE, MINIMUM HEMIN CHLORIDE BOVINE 12-diethenyl-3,8,13,17-tetramethyl-21h,23h-porphine-2,18-ferrate(2-chloro[7 Chloro(protoporphyrinato)iron(III), Chlorohemin, Chloroprotoporphyrin IX iron(III), Ferriprotoporphyrin IX chloride, Hemin(chloride) ChloroprotoferriheM Dihydrogen (SP-5-13)-chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-ferrate(2-) Ferriprotoporphyrin chloride Ferriheme chloride Hemin from porcine blood HEMIN PORCINE Chlorhaematin FerriheMe chloride CHLOROHEMIN Ferriporphyr in chloride Hemin Chloride - - Calbiochem HEMIN, PORCINE PHMACEUTICAL & BIOTECH ADE CHLOROFERRIPROTOPORPHYRIN Hemin (from porcine) EQUINE HEMIN HEMIN, PORCINE WATER SOLUABLE Chloro(protoporphyrinato)iron(III) MFCD00010726 Chloro[3,3'-(3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphyrindiyl-κN,N)dipropanoato(2-)]iron Hemin,Chloro(protoporphyrinato)iron(III), Chlorohemin, Chloroprotoporphyrin IX iron(III), Ferriprotoporphyrin IX chloride, Hemin(chloride) HEMIN ULTRA HeMatine hydrochloride FERRIPROTOPORPHRIN IX CHLORIDE n22,n23,n24]-,dihydrogen,(sp-5-13)-dipropanoato(4-)-n2 CHLOROPROTOPORPHYRIN IX IRON(III) HEMIN CRYST. ADE Hemin, bovine (crystalline) Ferriprotoporphyrin IX chloride Chloroprotoporphyrin IX iron(III) HeMin (porcine) CHLORO(PROTOPORPHYRINATO)IRON(III) HAEMIN Ferrate(2-), chloro[7,12-diethenyl-3,8, 13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato (4-)-N21,N22,N23,N24]-, dihydrogen, (SP-5-13) 7,12-Diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid HEMIN (EX PORCINE, BOVINE, EQUINE) Ferrate(2-), chloro7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24-, dihydrogen, (SP-5-13) Hemin In stock Factory Ferrate(2-),chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kN21,kN22,kN23,kN24]-, hydrogen (1:2), (SP-5-13) HEMIN, BOVINE HEMATIN HYDROCHLORIDE FERRIPROTOPORPHYRIN IX CHLORIDE EINECS 240-140-1 HEMIN CHLORIDE PROTOHEMIN IX Haemin,Crystalline HEMIN CHLORIDE PORCINE HEMIN,BOVINE,CRYSTAL Hematin chloride Ferriprotoporphyrine IX chloride, Hemin chloride 1,3,5,8-TetraMethy,4-divinylporphine-6,7-dipropionic acid ferrichloride HEMIN, BIOXTRA, FROM PORCINE, >=97.0 |
| Description | Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO)-1 inducer. |
|---|---|
| Related Catalog | |
| Target |
Heme oxygenase[1] |
| In Vitro | Hemin and PGJ2, used as positive controls, strongly increase both expression and activity of HMOX after 4 and 12 h, respectively. Indeed, a significant effect is found of 30 μM Hemin on cell proliferation in all used cell lines after 48 h, which is dose-dependent. Hemin treatment decreases cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons. Furthermore, enhancement of anti-proliferative effects of statins is observed by Hemin, documented as decreased cell proliferation after 48 h of co-treatment[1]. |
| In Vivo | Following the i.p. administration of Hemin (100 μmol/kg), the HO-1 level in the renal cortex begins to increase gradually. The HO-1 level reaches its peak 24 h after Hemin preconditioning. HO-1 is expressed mainly in the renal tubules. The HO-2 level in the kidney does not change following Hemin preconditioning[2]. |
| Cell Assay | For the cell proliferation assay, cells are seeded into 96 well (5-12.5×104 cells per mL according to the cell line) and kept at 37°C and 5 % CO2. After 24 h, cells are treated with statins or/and Hemin, followed by the MTT test as a general cell proliferation assay[1]. |
| Animal Admin | Mice[2] Eight- to ten-week-old male BABL/c mice are used for the ischemia-reperfusion (I/R) experiments. The animals are divided into five groups as follows: (1) the sham group undergo isolation of the bilateral renal arteries without clamping; (2) the vehicle group receive an intraperitoneal (i.p.) injection of 4 mL/kg PBS as a vehicle control (with IRI); (3) the Hemin-preconditioned group receive Hemin, a potent inducer of HO-1, at 100 μmol/kg i.p.; (4) the Hemin plus ZnPP group receive zinc protoporphyrin IX, an inhibitor of HO-1 activity, at 5 mg/kg i.p. 6 h after receiving 100 μmol/kg Hemin i.p.; and (5) the Hemin plus PD98059 group receive PD98059, an inhibitor of ERK1/2 activity, at 10 mg/kg i.p. 6 h after receiving 100 μmol/kg Hemin i.p. Both inhibitors are administered i.p. 2 h before I/R, whereas Hemin was administered 8 h before I/R. |
| References |
| Melting Point | 300 °C |
|---|---|
| Molecular Formula | C34H32ClFeN4O4 |
| Molecular Weight | 651.940 |
| Exact Mass | 651.146179 |
| PSA | 109.18000 |
| LogP | 4.29920 |
| Storage condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. Combustible. |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | N,Xi |
| Risk Phrases | R10:Flammable. R19:May form explosive peroxides. R50:Very Toxic to aquatic organisms. R36:Irritating to the eyes. |
| Safety Phrases | 24/25-22-36-26 |
| RIDADR | UN 3272 3/PG 3 |
| WGK Germany | 3 |
| RTECS | LJ8080000 |
| Packaging Group | III |
| Hazard Class | 3 |