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491-70-3

491-70-3 structure
491-70-3 structure
  • Name: Luteolin
  • Chemical Name: luteolin
  • CAS Number: 491-70-3
  • Molecular Formula: C15H10O6
  • Molecular Weight: 286.236
  • Catalog: API Respiratory medication Antitussive
  • Create Date: 2018-09-01 19:14:01
  • Modify Date: 2026-06-29 21:03:05
  • Luteolin is a falconoid compound, which exhibits anticancer properties.IC50 value:Target: A natural for anticancer.In vitro: Luteolin exerted an anticancer effect against NCI-H460 cells through Sirt1-mediated apoptosis and the inhibition of cell migration [1]. The treatment of luteolin upregulated the expression levels of transforming growth factor β1 (TGF-β1), p21WAF1/CIP1, p27KIP1, Smad4, and Fas in HCC cells. Luteolin induced apoptotic cell death in Hep3B cells while caused G1 arrest in HepG2 cells. And it induces apoptosis from G1 arrest via three signaling pathways of TGF-β1, p53, and Fas/Fas-ligand in HCC cells [2].In vivo: The study of the effect of Luteolin on the improvement of cancerous cachexia in model mice showed that luteolin can improve the symptoms of cancer cachexia model mice.The mechanism may be related to inhibition of proteasome and calcium activated protease activity and lower the levels of cytokines [3].
Name luteolin
Synonyms digitoflavone
3’,4’,5,7-tetrahydroxy-flavon
LUTEOLIN BY HPLC
Flavopurpol
3' 4' 5 7-tetrahydroxyflavone
Luteloin
peannt shell extract
cyanidenon digitoflavone 3',4',5,7-Tetrahydroxyflavone 5,7,3',4'-Tetrahydroxyflavone
3',4',5,7-tetrahydroxy-flavone
FLACITRAN
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
Daphneflavonol
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4h-1-benzopyran-4-on
5,7,3',4'-TETRAHYDROXYFLAVONE
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chroMen-4-one
Luteolin powder
cyanidenon
LUTEOLIN-3',7-O-DIGLUCURONIDE
Nano Liposomal Luteolin
c.i
Salifazide
MFCD08460272
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-benzopyran-4-one
EINECS 207-741-0
2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-4H-1-BENZOPYRAN-4-ONE
Rose extract P.E
LUTEOLOL
luteoline
YaMa Kiyasu
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-benzopyrone
RECHEM AB DU K001
3',4',5,7-TETRAHYDROXYFLAVONE,FLACITRAN,LUTEOLOL
Luteolin Synonyms : 3`,4`,5,7-Tetrahydroxyflavone
LUTEOLIN(SH)
Sophora flower bud extract
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-benzopyrone
5,7-dihydroxy
Luteolin extract powder
5,7,3',4'-tetrahydroxyflavon
uteoL
Luteolin(PeanutShellPe)ByHplc
LUTEOLIN hplc
Luteolin,3′,4′,5,7-Tetrahydroxyflavone
Luteolin -3
Luteolin (Digitoflavone)
Digitoflavone
5,7,3',4'-tetrahydroxyflavone
weldlake
Luteolin min
LUTEOLIN MONOHYDRATE
2-(3,4-DIHYDROXY-PHENYL)-5,7-DIHYDROXY-CHROMEN-4-ONE
LUTEOLIN(P)
c.i.naturalyellow2
Luteolin (Inedients)
Nano-Liposomal Luteolin,Water-Soluble Luteolin
Luteolin (6CI)
Luteolin //BP
Cyanidenon 1470
LUTEOLIN
Luteolin, >=(HPLC)
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy
Luteolin - - Calbiochem
Luteolin / luteoline
3’,4’,5,7-tetrahydroxyflavone Digitoflavone Cyanidenon
cyanidenon1470
4-(5,7-dihydroxy-4-oxo-1-benzopyran-2-yl)-2-hydroxyphenolate
3',4',5,7-Tetrahydroxyflavone
Description Luteolin is a falconoid compound, which exhibits anticancer properties.IC50 value:Target: A natural for anticancer.In vitro: Luteolin exerted an anticancer effect against NCI-H460 cells through Sirt1-mediated apoptosis and the inhibition of cell migration [1]. The treatment of luteolin upregulated the expression levels of transforming growth factor β1 (TGF-β1), p21WAF1/CIP1, p27KIP1, Smad4, and Fas in HCC cells. Luteolin induced apoptotic cell death in Hep3B cells while caused G1 arrest in HepG2 cells. And it induces apoptosis from G1 arrest via three signaling pathways of TGF-β1, p53, and Fas/Fas-ligand in HCC cells [2].In vivo: The study of the effect of Luteolin on the improvement of cancerous cachexia in model mice showed that luteolin can improve the symptoms of cancer cachexia model mice.The mechanism may be related to inhibition of proteasome and calcium activated protease activity and lower the levels of cytokines [3].
Related Catalog
References

[1]. Liping Ma, et al. Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of Sirt1-mediated apoptosis. Molecular MedicineReports, 2015, 12 (3): 4196-4202

[2]. Su Bog Yee, et al. Growth inhibition of luteolin on HepG2 cells is induced via p53 and Fas/Fas-ligand besides the TGF-β pathway. International Journal of Oncology, 2015, 47 (2): 747-754

[3]. Pang Tao, et al. Effect of Luteolin on the Improvement of Cancerous Cachexia in Model Mice. China Pharmacy, 2015-07

[4]. Divyashree Ravishankar, et al. Exploring quercetin and luteolin derivatives as antiangiogenic agents. European Journal of Medicinal ChemistryVolume 97, 5 June 2015, Pages 259–274
Density 1.7±0.1 g/cm3
Boiling Point 616.1±55.0 °C at 760 mmHg
Melting Point ~330 °C(lit.)
Molecular Formula C15H10O6
Molecular Weight 286.236
Flash Point 239.5±25.0 °C
Exact Mass 286.047729
PSA 111.13000
LogP 2.40
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.768
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LK9275210
CHEMICAL NAME :
Flavone, 3',4',5,7-tetrahydroxy-
CAS REGISTRY NUMBER :
491-70-3
BEILSTEIN REFERENCE NO. :
0292084
LAST UPDATED :
199806
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C15-H10-O6
MOLECULAR WEIGHT :
286.25
WISWESSER LINE NOTATION :
T66 BO EVT&J CR CQ DQ& GQ IQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
50 mg/kg
SEX/DURATION :
female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

MUTATION DATA

TYPE OF TEST :
Sex chromosome loss and nondisjunction
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
20 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 246,205,1991
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS LK9275210
HS Code 2932999099
HS Code 2914501900
Summary 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
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