29080-58-8

29080-58-8 structure

Name: 5-Hydroxy-3',4',7-trimethoxyflavone
Chemical Name: 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one
CAS Number: 29080-58-8
Molecular Formula: C₁₈H₁₆O₆
Molecular Weight: 328.316
Catalog: Natural product Flavonoids
Create Date: 2016-06-09 23:56:31
Modify Date: 2024-01-02 18:09:56
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid from the herb Lippia nodiflora L. (Verbenaceae) which has been documented to exhibit anti-inflammatory, antipyretic, antitussive, antidiabetic, anticancer, and antimelanogenesis properties. 7,3',4'-Tri-O-methylluteolin obviously reduces the prodn of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β in a concentration-dependent manner. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2, representing that inhibition occurs at the transcriptional level[1].

Name	2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one
Synonyms	4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxy- 2-(3,4-Dimethoxyphenyl)-5-hydroxy-7-methoxy-4H-chromen-4-one 5-Hydroxy-3',4',7-trimethoxyflavone luteolin-3'-4',7-trimethyl ether 5-hydroxy-7,2',6'-trimethoxyflavone 5-hydroxy-7,3',4'-trimethoxy-flavone Luteolin-7,3',4'-trimethylether 5-hydroxy-7,3',4'-trimethoxyflavone

Description	7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid from the herb Lippia nodiflora L. (Verbenaceae) which has been documented to exhibit anti-inflammatory, antipyretic, antitussive, antidiabetic, anticancer, and antimelanogenesis properties. 7,3',4'-Tri-O-methylluteolin obviously reduces the prodn of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β in a concentration-dependent manner. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2, representing that inhibition occurs at the transcriptional level[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology Signaling Pathways >> Apoptosis >> TNF Receptor Research Areas >> Metabolic Disease
Target	TNF-α IL-6 IL-1β
References	[1]. Sudha, A, et al. Protective effect of 5-hydroxy-3′,4′,7-trimethoxyflavone against inflammation induced by lipopolysaccharide in RAW 264.7 macrophage: in vitro study and in silico validation. Medicinal Chemistry Research, 2016,25(9), 1754–1767.

Hazard Codes	Xi
HS Code	2932999099

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%