CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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OZ4375000
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CHEMICAL NAME :
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Methacrylic acid, 2,3-epoxypropyl ester
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CAS REGISTRY NUMBER :
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106-91-2
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BEILSTEIN REFERENCE NO. :
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0002506
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LAST UPDATED :
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199806
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DATA ITEMS CITED :
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26
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MOLECULAR FORMULA :
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C7-H10-O3
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MOLECULAR WEIGHT :
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142.17
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WISWESSER LINE NOTATION :
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T3OTJ B1OVY1&U1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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597 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1400 mg/m3/6H
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - other changes
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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390 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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1400 mg/m3/6H
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - other changes
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TYPE OF TEST :
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LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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1400 mg/m3/6H
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - other changes
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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450 uL/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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697 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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1400 mg/m3/6H
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - other changes
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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2100 mg/kg/30D-I
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TOXIC EFFECTS :
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Behavioral - food intake (animal) Gastrointestinal - ulceration or bleeding from stomach Kidney, Ureter, Bladder - changes primarily in glomeruli
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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206 mg/m3/6H/26W-I
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TOXIC EFFECTS :
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Liver - changes in liver weight Endocrine - changes in spleen weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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40 ppm/6H/9D-I
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Olfaction) - deviated nasal septum Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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206 mg/m3/6H/26W-I
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TOXIC EFFECTS :
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Brain and Coverings - other degenerative changes Cardiac - EKG changes not diagnostic of specified effects Blood - changes in erythrocyte (RBC) count
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TYPE OF TEST :
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Cytogenetic analysis
MUTATION DATA
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TYPE OF TEST :
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Sister chromatid exchange
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TEST SYSTEM :
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Rodent - hamster Lung
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DOSE/DURATION :
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78 umol/L
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REFERENCE :
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MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 249,55,1991 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-THE NETHERLANDS:TWA 0.04 ppm (0.24 mg/m3) JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1341 No. of Facilities: 95 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 4002 (estimated)
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