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3093-35-4

3093-35-4 structure
3093-35-4 structure
  • Name: Halcinonide
  • Chemical Name: halcinonide
  • CAS Number: 3093-35-4
  • Molecular Formula: C24H32ClFO5
  • Molecular Weight: 454.959
  • Catalog: API Hormone and endocrine-regulating drugs Adrenal corticosteroids
  • Create Date: 2018-06-12 12:43:16
  • Modify Date: 2024-01-02 18:16:29
  • Halcinonide (SQ-18566) is a high potency corticosteroid used topically in the treatment of certain skin conditions.
Name halcinonide
Synonyms Alcinonide
Halcort
21-Chloro-9a-fluoro-11b-hydroxy-16a,17a-isopropylidenedioxy-4-pregnene-3,20-dione
Halcimat
(11b,16a)-21-Chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-6b-(chloroacétyl)-4b-fluoro-5-hydroxy-4a,6a,8,8-tétraméthyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tétradécahydro-2H-naphto[2',1':4,5]indéno[1,2-d][1,3]dioxol-2-one
2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 6b-(2-chloroacetyl)-4b-fluoro-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-5-hydroxy-4a,6a,8,8-tetramethyl-, (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-
UNII-SI86V6QNEG
Halciderm
2H-naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 6b-(chloroacetyl)-4b-fluoro-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-5-hydroxy-4a,6a,8,8-tetramethyl-, (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-
Halog
(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-6b-(Chloracetyl)-4b-fluor-5-hydroxy-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
EINECS 221-439-6
halcinomide
Halcinonide
MFCD00866006
(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-6b-(Chloroacetyl)-4b-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
UNII:SI86V6QNEG
Description Halcinonide (SQ-18566) is a high potency corticosteroid used topically in the treatment of certain skin conditions.
Related Catalog
References

[1]. Pujos E, et al. Comparison of the analysis of corticosteroids using different techniques. Anal Bioanal Chem. 2005 Jan;381(1):244-54.
Density 1.3±0.1 g/cm3
Boiling Point 564.3±50.0 °C at 760 mmHg
Molecular Formula C24H32ClFO5
Molecular Weight 454.959
Flash Point 295.1±30.1 °C
Exact Mass 454.192230
PSA 72.83000
LogP 3.31
Vapour Pressure 0.0±3.5 mmHg at 25°C
Index of Refraction 1.567

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU5010200
CHEMICAL NAME :
Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-beta,16-alpha,17-trihydroxy-, cyclic 16,17-acetal with acetone
CAS REGISTRY NUMBER :
3093-35-4
BEILSTEIN REFERENCE NO. :
1358242
LAST UPDATED :
199612
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C24-H32-Cl-F-O5
MOLECULAR WEIGHT :
455.01
WISWESSER LINE NOTATION :
T F5 E5 B666 GO IO RV PUTJ A1 BF CQ E1 FV1G H1 H1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
39800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
95500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
409 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4375 ug/kg/1W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight Endocrine - changes in spleen weight Endocrine - changes in thymus weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4375 ug/kg/5W-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
455 mg/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
45500 ug/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
136 mg/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - other changes

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Cells - not otherwise specified
DOSE/DURATION :
1 nmol/L
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,1782,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6056 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 794 (estimated) No. of Female Employees: 419 (estimated)
Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H361
Precautionary Statements P280
Hazard Codes Xn:Harmful
Risk Phrases R63
Safety Phrases S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TU5010200
82427-96-1 structure

82427-96-1

~67%

3093-35-4 structure

3093-35-4

Literature: Annen, Klaus; Hofmeister, Helmut; Laurent, Henry; Wiechert, Rudolf Liebigs Annalen der Chemie, 1982 , # 5 p. 966 - 972
82427-95-0 structure

82427-95-0

~%

3093-35-4 structure

3093-35-4

Literature: Liebigs Annalen der Chemie, , # 5 p. 966 - 972
Precursor  2

DownStream  0


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