41743-73-1

41743-73-1 structure

Name: Irisflorentin
Chemical Name: 9-methoxy-7-(3,4,5-trimethoxyphenyl)-[1,3]dioxolo[4,5-g]chromen-8-one
CAS Number: 41743-73-1
Molecular Formula: C₂₀H₁₈O₈
Molecular Weight: 386.352
Catalog: Biochemical Plant extracts
Create Date: 2018-07-11 15:56:39
Modify Date: 2024-01-02 11:53:04
Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Rhizoma Belamcandae. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity[1].

Name	9-methoxy-7-(3,4,5-trimethoxyphenyl)-[1,3]dioxolo[4,5-g]chromen-8-one
Synonyms	Irisflorentin 3',4',5',5-tetramethoxy-6,7-methylenedioxyisoflavone irisflorentine 9-methoxy-7-(3,4,5-trimethoxy-phenyl)-[1,3]dioxolo[4,5-g]chromen-8-one 9-Methoxy-7-(3,4,5-trimethoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromen-8-one 9-Methoxy-7-(3,4,5-trimethoxyphenyl)-8H-1,3-dioxolo[4,5-g][1]benzopyran-8-one 8H-1,3-Dioxolo[4,5-g][1]benzopyran-8-one, 9-methoxy-7-(3,4,5-trimethoxyphenyl)- N1426 9-Methoxy-7-(3,4,5-trimethoxyphenyl)-8H-1,3-dioxolo(4,5-g)(1)benzopyran-8-one 5,3',4',5'-Tetramethoxy-6,7-methylenedioxyisoflavone 8H-1,3-Dioxolo(4,5-g)(1)benzopyran-8-one, 9-methoxy-7-(3,4,5-trimethoxyphenyl)-

Description	Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Rhizoma Belamcandae. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology
In Vitro	Irisflorentin does not affect the LPS-stimulated RAW 264.7 macrophages viability up to a concentration of 40 μM[1]. Irisflorentin (10-40 μM) inhibits the LPS-induced production of NO in a concentration-dependent manner without affecting the iNOS activity in RAW 264.7 macrophages[1]. Irisflorentin (10-40 μM) concentration dependently inhibits the LPS (10 ng/mL)-induced increase in iNOS mRNA expression in LPS stimulated RAW 264.7 macrophages. Irisflorentin (10-40 μM) concentration-dependently suppresses the production of TNF-α, IL-1β and IL-6 in LPS stimulated RAW 264.7 macrophages[1]. Irisflorentin (10-40 μM) concentration dependently inhibits the LPS (10 ng/mL)-induced increase in iNOS protein levels. Irisflorentin (10-40 μM) concentration-dependently suppresses LPS-induced p38 and ERK1/2 phosphorylation in a concentration-dependent manner, but slightly affects JNK phosphorylation[1]. RT-PCR[1] Cell Line: LPS-stimulated RAW 264.7 macrophages Concentration: 10, 20, 40 μM Incubation Time: Result: Inhibited the LPS (10 ng/mL)-induced increase in iNOS mRNA expression. Suppressed the production of TNF-α, IL-1β and IL-6. Western Blot Analysis[1] Cell Line: LPS-stimulated RAW 264.7 macrophages Concentration: 10, 20, 40 μM Incubation Time: Result: Inhibited the LPS (10 ng/mL)-induced increase in iNOS protein levels. Suppressed LPS-induced p38 and ERK1/2 phosphorylation, but slightly affected JNK phosphorylation.
References	[1]. Gao Y, et al. Suppressive effects of irisflorentin on LPS-induced inflammatory responses in RAW 264.7 macrophages. Exp Biol Med (Maywood). 2014 Aug;239(8):1018-1024.

Density	1.3±0.1 g/cm3
Boiling Point	569.1±50.0 °C at 760 mmHg
Melting Point	169 °C
Molecular Formula	C₂₀H₁₈O₈
Molecular Weight	386.352
Flash Point	250.5±30.2 °C
Exact Mass	386.100159
PSA	85.59000
LogP	3.19
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.593
Storage condition	2-8°C

Safety Phrases	24/25
RIDADR	NONH for all modes of transport
HS Code	2932999099

Precursor 7
3840-31-1 13338-63-1 1916-07-0 61404-52-2
62616-09-5 86-81-7 50901-33-2
DownStream 0

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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