Irisflorentin

Modify Date: 2024-01-02 11:53:04

Irisflorentin Structure
Irisflorentin structure
 Common Name Irisflorentin
CAS Number 41743-73-1 Molecular Weight 386.352
Density 1.3±0.1 g/cm3 Boiling Point 569.1±50.0 °C at 760 mmHg
Molecular Formula C20H18O8 Melting Point 169 °C
MSDS N/A Flash Point 250.5±30.2 °C

 Use of Irisflorentin


Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Rhizoma Belamcandae. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity[1].

 Names

Name 9-methoxy-7-(3,4,5-trimethoxyphenyl)-[1,3]dioxolo[4,5-g]chromen-8-one
Synonym More Synonyms

 Irisflorentin Biological Activity

Description Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Rhizoma Belamcandae. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity[1].
Related Catalog
In Vitro Irisflorentin does not affect the LPS-stimulated RAW 264.7 macrophages viability up to a concentration of 40 μM[1]. Irisflorentin (10-40 μM) inhibits the LPS-induced production of NO in a concentration-dependent manner without affecting the iNOS activity in RAW 264.7 macrophages[1]. Irisflorentin (10-40 μM) concentration dependently inhibits the LPS (10 ng/mL)-induced increase in iNOS mRNA expression in LPS stimulated RAW 264.7 macrophages. Irisflorentin (10-40 μM) concentration-dependently suppresses the production of TNF-α, IL-1β and IL-6 in LPS stimulated RAW 264.7 macrophages[1]. Irisflorentin (10-40 μM) concentration dependently inhibits the LPS (10 ng/mL)-induced increase in iNOS protein levels. Irisflorentin (10-40 μM) concentration-dependently suppresses LPS-induced p38 and ERK1/2 phosphorylation in a concentration-dependent manner, but slightly affects JNK phosphorylation[1]. RT-PCR[1] Cell Line: LPS-stimulated RAW 264.7 macrophages Concentration: 10, 20, 40 μM Incubation Time: Result: Inhibited the LPS (10 ng/mL)-induced increase in iNOS mRNA expression. Suppressed the production of TNF-α, IL-1β and IL-6. Western Blot Analysis[1] Cell Line: LPS-stimulated RAW 264.7 macrophages Concentration: 10, 20, 40 μM Incubation Time: Result: Inhibited the LPS (10 ng/mL)-induced increase in iNOS protein levels. Suppressed LPS-induced p38 and ERK1/2 phosphorylation, but slightly affected JNK phosphorylation.
References

[1]. Gao Y, et al. Suppressive effects of irisflorentin on LPS-induced inflammatory responses in RAW 264.7 macrophages. Exp Biol Med (Maywood). 2014 Aug;239(8):1018-1024.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 569.1±50.0 °C at 760 mmHg
Melting Point 169 °C
Molecular Formula C20H18O8
Molecular Weight 386.352
Flash Point 250.5±30.2 °C
Exact Mass 386.100159
PSA 85.59000
LogP 3.19
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.593
Storage condition 2-8°C

 Safety Information

Safety Phrases 24/25
RIDADR NONH for all modes of transport
HS Code 2932999099

 Synthetic Route

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Irisflorentin
3',4',5',5-tetramethoxy-6,7-methylenedioxyisoflavone
irisflorentine
9-methoxy-7-(3,4,5-trimethoxy-phenyl)-[1,3]dioxolo[4,5-g]chromen-8-one
9-Methoxy-7-(3,4,5-trimethoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromen-8-one
9-Methoxy-7-(3,4,5-trimethoxyphenyl)-8H-1,3-dioxolo[4,5-g][1]benzopyran-8-one
8H-1,3-Dioxolo[4,5-g][1]benzopyran-8-one, 9-methoxy-7-(3,4,5-trimethoxyphenyl)-
N1426
9-Methoxy-7-(3,4,5-trimethoxyphenyl)-8H-1,3-dioxolo(4,5-g)(1)benzopyran-8-one
5,3',4',5'-Tetramethoxy-6,7-methylenedioxyisoflavone
8H-1,3-Dioxolo(4,5-g)(1)benzopyran-8-one, 9-methoxy-7-(3,4,5-trimethoxyphenyl)-
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  • Product Name: Irisflorentin
  • Price: ￥Inquiry/50mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng

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Chemsrc provides Irisflorentin(CAS#:41743-73-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Irisflorentin are included as well.>> amp version: Irisflorentin

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