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81-61-8

81-61-8 structure
81-61-8 structure
  • Name: Quinalizarin
  • Chemical Name: quinalizarin
  • CAS Number: 81-61-8
  • Molecular Formula: C14H8O6
  • Molecular Weight: 272.210
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Casein Kinase
  • Create Date: 2018-09-17 00:31:08
  • Modify Date: 2024-01-12 10:02:13
  • Quinalizarin is a potent, selective and cell-permeable protein kinase CK2 inhibitor with an Ki of ~50 nM and an IC50 of 110 nM. Quinalizarin can induce apoptosis of certain cancer cells[1].
Name quinalizarin
Synonyms 1,2,5,8-tetrahydroxy-9,10-anthracenedione
Alizarinbordeaux
9,10-Anthracenedione, 1,2,5,8-tetrahydroxy-
MFCD00001205
9,10-Anthracenedione,1,2,5,8-tetrahydroxy
Alizarine Bordeaux B
1,2,5,8-Tetrahydroxy-9,10-anthraquinone
Mordant Violet 26
Khinalizarin
Alizarine Bordeaux
C.I. Mordant Violet 26
Alizarin bordeaux B
1,2,5,8-tetrahydroxyanthracene-9,10-dione
Quinalizarin
1,2,5,8-tetrahydroxyanthraquinone
EINECS 201-366-6
Description Quinalizarin is a potent, selective and cell-permeable protein kinase CK2 inhibitor with an Ki of ~50 nM and an IC50 of 110 nM. Quinalizarin can induce apoptosis of certain cancer cells[1].
Related Catalog
Target

CK2:~50 nM (Ki)

CK2:110 nM (IC50)
References

[1]. Cozza G, et al. Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2. Biochem J. 2009;421(3):387-395. Published 2009 Jul 15.
Density 1.8±0.1 g/cm3
Boiling Point 517.1±45.0 °C at 760 mmHg
Melting Point 99 °C
Molecular Formula C14H8O6
Molecular Weight 272.210
Flash Point 280.6±25.2 °C
Exact Mass 272.032074
PSA 115.06000
LogP 5.18
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.815
Storage condition room temp

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CB8069900
CHEMICAL NAME :
Anthraquinone, 1,2,5,8-tetrahydroxy-
CAS REGISTRY NUMBER :
81-61-8
BEILSTEIN REFERENCE NO. :
1889617
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C14-H8-O6
MOLECULAR WEIGHT :
272.22
WISWESSER LINE NOTATION :
L C666 BV IVJ DQ EQ KQ NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
50 ug/plate
REFERENCE :
BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973- Volume(issue)/page/year: 5,1489,1977
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H400
Precautionary Statements P273
Hazard Codes Xn,N
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR UN 3077 9 / PGIII
72-48-0 structure

72-48-0

~%

81-61-8 structure

81-61-8
Literature: DE60855 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 3, p. 198 Journal fuer Praktische Chemie (Leipzig), , vol. <2>43, p. 239 Chemische Berichte, , vol. 23, p. 3739 Justus Liebigs Annalen der Chemie, , vol. 349, p. 205
518-90-1 structure

518-90-1
123-31-9 structure

123-31-9

~%

81-61-8 structure

81-61-8
Literature: Justus Liebigs Annalen der Chemie, , vol. 240, p. 301
14597-12-7 structure

14597-12-7
120-80-9 structure

120-80-9

~%

81-61-8 structure

81-61-8
Literature: Journal of Organic Chemistry, , vol. 6, p. 732,747 Journal of Organic Chemistry, , vol. 7, p. 63,66
81-64-1 structure

81-64-1

~%

81-61-8 structure

81-61-8
Literature: DE63693 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 3, p. 201 Journal fuer Praktische Chemie (Leipzig), , vol. <2>43, p. 249
81-64-1 structure

81-64-1
7664-93-9 structure

7664-93-9
13460-50-9 structure

13460-50-9

~%

81-61-8 structure

81-61-8
Literature: DE161026 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 8, p. 256

Chemsrc provides CAS#:81-61-8 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 81-61-8 | Chemsrc address: https://m.chemsrc.com/en/baike/952770.html

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