Quinalizarin

Modify Date: 2024-01-12 10:02:13

Quinalizarin structure	Common Name	Quinalizarin
	CAS Number	81-61-8	Molecular Weight	272.210
	Density	1.8±0.1 g/cm3	Boiling Point	517.1±45.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₈O₆	Melting Point	99 °C
	MSDS	Chinese USA	Flash Point	280.6±25.2 °C
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of Quinalizarin

Quinalizarin is a potent, selective and cell-permeable protein kinase CK2 inhibitor with an Ki of ~50 nM and an IC50 of 110 nM. Quinalizarin can induce apoptosis of certain cancer cells[1].

Name	quinalizarin
Synonym	More Synonyms

Description	Quinalizarin is a potent, selective and cell-permeable protein kinase CK2 inhibitor with an Ki of ~50 nM and an IC50 of 110 nM. Quinalizarin can induce apoptosis of certain cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase
Target	CK2:~50 nM (Ki) CK2:110 nM (IC50)
References	[1]. Cozza G, et al. Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2. Biochem J. 2009;421(3):387-395. Published 2009 Jul 15.

Density	1.8±0.1 g/cm3
Boiling Point	517.1±45.0 °C at 760 mmHg
Melting Point	99 °C
Molecular Formula	C₁₄H₈O₆
Molecular Weight	272.210
Flash Point	280.6±25.2 °C
Exact Mass	272.032074
PSA	115.06000
LogP	5.18
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.815
Storage condition	room temp

Quinalizarin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB8069900

CHEMICAL NAME :: Anthraquinone, 1,2,5,8-tetrahydroxy-

CAS REGISTRY NUMBER :: 81-61-8

BEILSTEIN REFERENCE NO. :: 1889617

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H8-O6

MOLECULAR WEIGHT :: 272.22

WISWESSER LINE NOTATION :: L C666 BV IVJ DQ EQ KQ NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 50 ug/plate

REFERENCE :: BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973- Volume(issue)/page/year: 5,1489,1977

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H400
Precautionary Statements	P273
Hazard Codes	Xn,N
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	UN 3077 9 / PGIII

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Protein kinase CK2 potentiates translation efficiency by phosphorylating eIF3j at Ser127.

Biochim. Biophys. Acta 1853 , 1693-701, (2015)

In eukaryotic protein synthesis the translation initiation factor 3 (eIF3) is a key player in the recruitment and assembly of the translation initiation machinery. Mammalian eIF3 consists of 13 subuni...

A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression.

Cell. Mol. Life Sci. 71(21) , 4243-58, (2014)

Hepatitis C virus (HCV) infection is associated with hepatic iron overload and elevated serum iron that correlate to poor antiviral responses. Hepcidin (HAMP), a 25-aa cysteine-rich liver-specific pep...

Quinalizarin enhances radiosensitivity of nasopharyngeal carcinoma cells partially by suppressing SHP-1 expression.

Int. J. Oncol. 48 , 1073-84, (2016)

The purpose of this study was to investigate the influence of quinalizarin on the radiosensitivity of nasopharyngeal carcinoma (NPC) cells and the relevant underlying mechanisms. Human NPC cell lines ...

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Quinalizarin

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EINECS 201-366-6

DC Chemicals Limited
China
Product Name: Quinalizarin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,2,5,8-Tetrahydroxyanthraquinone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Quinalizarin

Use of Quinalizarin

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Quinalizarin Biological Activity

Chemical & Physical Properties

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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Precursor & DownStream

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