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Product Name: 1,2-Ethanediamine,N1,N1-dimethyl-N2-(phenylmethyl)-N2-2-pyridinyl-
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91-81-6

91-81-6 structure

Name: Tripelennamine
Chemical Name: N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine
CAS Number: 91-81-6
Molecular Formula: C₁₆H₂₁N₃
Molecular Weight: 255.35800
Catalog: API Antiallergic Antihistamine
Create Date: 2018-06-25 21:11:31
Modify Date: 2024-01-03 13:00:19
Tripelennamine, an ethylenediamine derivative, is a potent histamine H1-receptor antagonist. Tripelennamine lessens the allergic response of the organism caused by histamine. Tripelennamine can be used for the research of rhinitis, conjunctivitis, and allergic and anaphylactic reactions[1][2][3].

Name	N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine
Synonyms	Piribenzil Tonaril N-benzyl-N',N'-dimethyl-N-pyridin-2-yl-ethane-1,2-diamine Benzoxale Tripelennamin Pyribenzamine Cizaron N-benzyl-N',N'-dimethyl-N-[2]pyridyl-ethylenediamine Resistamine tripelenamin Tripelennamina tripelennamine Pyrinamine base

Description	Tripelennamine, an ethylenediamine derivative, is a potent histamine H1-receptor antagonist. Tripelennamine lessens the allergic response of the organism caused by histamine. Tripelennamine can be used for the research of rhinitis, conjunctivitis, and allergic and anaphylactic reactions[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Endocrinology Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H1 Receptor
References	[1]. Manohar M, et al. H1-receptor antagonist, tripelennamine, does not affect arterial hypoxemia in exercising Thoroughbreds. J Appl Physiol. 2002 Apr;92(4):1515-23. [2]. Wasfi IA, et al. Comparative disposition of tripelennamine in horses and camels after intravenous administration. J Vet Pharmacol Ther. 2000 Jun;23(3):145-52. [3]. Yeh SY, et al. The pharmacokinetics of pentazocine and tripelennamine. Clin Pharmacol Ther. 1986 Jun;39(6):669-76.

Density	1.0683 (rough estimate)
Boiling Point	185 - 190ºC at 1.7 mm Hg
Melting Point	25°C
Molecular Formula	C₁₆H₂₁N₃
Molecular Weight	255.35800
Exact Mass	255.17400
PSA	19.37000
LogP	2.64980
Index of Refraction	nD25 1.5759-1.5765

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US2800000

CHEMICAL NAME :: Pyridine, 2-(benzyl(2-(dimethylamino)ethyl)amino)-

CAS REGISTRY NUMBER :: 91-81-6

BEILSTEIN REFERENCE NO. :: 0227074

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C16-H21-N3

MOLECULAR WEIGHT :: 255.40

WISWESSER LINE NOTATION :: T6NJ BN1R&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 152 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 43 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 61 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Human Liver

DOSE/DURATION :: 10 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 173,229,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 74620 No. of Facilities: 26 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1324 (estimated) No. of Female Employees: 667 (estimated)

872298-31-2

124-40-3

~75%

91-81-6

Literature: Hamid, M. Haniti S. A.; Allen, C. Liana; Lamb, Gareth W.; Maxwell, Aoife C.; Maytum, Hannah C.; et al. Journal of the American Chemical Society, 2009 , vol. 131, p. 1766 - 1774

23826-72-4

91-81-6

Literature: Gogate, Priyanka N.; Ethirajan, Manivannan; Kurenova, Elena V.; Magis, Andrew T.; Pandey, Ravindra K.; Cance, William G. European Journal of Medicinal Chemistry, 2014 , vol. 80, p. 154 - 156

109-09-1

91-81-6

Precursor 4
872298-31-2 124-40-3 23826-72-4 109-09-1
DownStream 0

91-81-6	154-69-8
6138-56-3	22306-05-4