175013-84-0
175013-84-0 structure
- Name: Tonabersat
- Chemical Name: N-[(3S,4S)-6-acetyl-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-3-chloro-4-fluorobenzamide
- CAS Number: 175013-84-0
- Molecular Formula: C20H19ClFNO4
- Molecular Weight: 391.82100
- Catalog: Signaling Pathways Cytoskeleton Gap Junction Protein
- Create Date: 2018-12-27 19:24:29
- Modify Date: 2025-08-22 11:28:25
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Tonabersat is a gap-junction modulator.
| Name | N-[(3S,4S)-6-acetyl-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-3-chloro-4-fluorobenzamide |
|---|---|
| Synonyms |
Tonabersat
Tonabersat [BAN,INN] UNII-2XD9773ZMN USL-260 |
| Description | Tonabersat is a gap-junction modulator. |
|---|---|
| Related Catalog | |
| Target |
Gap-junction[1] |
| In Vitro | Tonabersat, a novel benzopyran derivative, inhibits cortical spreading depression (CSD) and therefore might be able to inhibit the early migraine mechanisms[1]. |
| In Vivo | Treatment with either Tonabersat (10 mg/kg) or Meclofenamate (20 mg/kg) as single agents significantly inhibit progression of metastatic lesions. Addition of carboplatin to either agent profoundly inhibits brain metastasis[2]. |
| Animal Admin | Mice[2] Athymic NCR nu/nu mice, Cr:NIH bg-nu-xid mice, B6129SF1/J, C57BL/6J-Tmem173gt/J 'golden ticket', and C57/Bl/6J mice are used at 5-6 weeks of age. For inducible knockdown experiments, mice are given doxycycline hyclate in the drinking water (2 mg/mL) and the diet 14 days after injection of cancer cells. For drug treatment experiments, mice are intraperitoneally injected with Carboplatin (5 mg/kg per 5 days), Tonabersat (MedChem Express) (10 mg/kg per day), or meclofenamic acid sodium salt (20 mg/kg per day). Vehicle (10% DMSO in polyethylene glycol 400) is used in control mice. Quantification of tumour burden is by Bio-luminescent imaging (BLI), performed using an IVIS Spectrum Xenogen instrument and analysed using Living Image software v.2.50. |
| References |
| Density | 1.38g/cm3 |
|---|---|
| Boiling Point | 554.5ºC at 760 mmHg |
| Molecular Formula | C20H19ClFNO4 |
| Molecular Weight | 391.82100 |
| Flash Point | 289.2ºC |
| Exact Mass | 391.09900 |
| PSA | 75.63000 |
| LogP | 4.07560 |
| Vapour Pressure | 3.94E-13mmHg at 25°C |
| Index of Refraction | 1.612 |
| Storage condition | 2-8℃ |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H400 |
| Precautionary Statements | P273-P280-P305 + P351 + P338-P337 + P313-P391 |
| RIDADR | UN 3077 9 / PGIII |