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327-57-1

327-57-1 structure
327-57-1 structure
Name Hexanoic acid, 2-amino-, (S)
Synonyms L-2-Aminohexanoic acid
EINECS 206-321-4
(S)-Norleucine
Norleucine
(S)-2-amino-Hexanoic acid
(S)-(+)-2-Aminohexanoic acid
H-L-NLE-OH
Glycoleucine
H-L-NORLEUCINE
L-Norleucine
(S)-(+)-2-Aminohexanoic acid (S)-2-Aminocaproic acid
(S)-Aminohexanoic acid
(S)-a-Aminocaproic acid
L-2-Amino-hexanoic acid
L-Aminohexanoic acid
Norleucine, L-
(S)-2-Aminohexanoic acid
caprine
H-NLE-OH
H-ACPO(2)-OH
L-2-aminohexanoate
H-AHX(2)-OH
D,L-Norleucine
MFCD00064423
L(+)-Norleucine
(S)-2-aminocaproic acid
N-NORLEUCINE
Description L-Norleucine is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro L-Norleucine is an isomer of leucine, specifically affecting protein synthesis in skeletal muscle[1]. L-Norleucine has antiviral activity. L-Norleucine interacts with hnRNPA2/B1 protein to suppresses the expressions of Twist1 and Snail, two inhibitors of E-cadherin, and promotes the expression of E-cadherin, resulting in the inhibition of tumor metastasis[2].
References

[1]. Schott KJ, et al. On the role of branched-chain amino acids in protein turnover of skeletal muscle. Studies in vivo with L-norleucine. Z Naturforsch C. 1985 May-Jun;40(5-6):427-37.

[2]. He T, et al. The homeostasis-maintaining metabolites from bacterial stress response to bacteriophage infection suppress tumor metastasis. Oncogene. 2018 Jun 20.
Density 1.0±0.1 g/cm3
Boiling Point 234.0±23.0 °C at 760 mmHg
Melting Point 300ºC
Molecular Formula C6H13NO2
Molecular Weight 131.173
Flash Point 95.3±22.6 °C
Exact Mass 131.094635
PSA 63.32000
LogP 0.92
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.465

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RC6308000
CHEMICAL NAME :
Norleucine, L-
CAS REGISTRY NUMBER :
327-57-1
BEILSTEIN REFERENCE NO. :
1721750
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C6-H13-N-O2
MOLECULAR WEIGHT :
131.20
WISWESSER LINE NOTATION :
ZY4&VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Microorganism - not otherwise specified
DOSE/DURATION :
100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 12,349,1971
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H317
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R43
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS RC6308000
HS Code 29224995
HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%
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