L-Norleucine

Modify Date: 2024-01-02 10:21:42

L-Norleucine Structure
L-Norleucine structure
Common Name L-Norleucine
CAS Number 327-57-1 Molecular Weight 131.173
Density 1.0±0.1 g/cm3 Boiling Point 234.0±23.0 °C at 760 mmHg
Molecular Formula C6H13NO2 Melting Point 300ºC
MSDS Chinese USA Flash Point 95.3±22.6 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of L-Norleucine


L-Norleucine is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

 Names

Name Hexanoic acid, 2-amino-, (S)
Synonym More Synonyms

 L-Norleucine Biological Activity

Description L-Norleucine is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro L-Norleucine is an isomer of leucine, specifically affecting protein synthesis in skeletal muscle[1]. L-Norleucine has antiviral activity. L-Norleucine interacts with hnRNPA2/B1 protein to suppresses the expressions of Twist1 and Snail, two inhibitors of E-cadherin, and promotes the expression of E-cadherin, resulting in the inhibition of tumor metastasis[2].
References

[1]. Schott KJ, et al. On the role of branched-chain amino acids in protein turnover of skeletal muscle. Studies in vivo with L-norleucine. Z Naturforsch C. 1985 May-Jun;40(5-6):427-37.

[2]. He T, et al. The homeostasis-maintaining metabolites from bacterial stress response to bacteriophage infection suppress tumor metastasis. Oncogene. 2018 Jun 20.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 234.0±23.0 °C at 760 mmHg
Melting Point 300ºC
Molecular Formula C6H13NO2
Molecular Weight 131.173
Flash Point 95.3±22.6 °C
Exact Mass 131.094635
PSA 63.32000
LogP 0.92
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.465

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RC6308000
CHEMICAL NAME :
Norleucine, L-
CAS REGISTRY NUMBER :
327-57-1
BEILSTEIN REFERENCE NO. :
1721750
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C6-H13-N-O2
MOLECULAR WEIGHT :
131.20
WISWESSER LINE NOTATION :
ZY4&VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Microorganism - not otherwise specified
DOSE/DURATION :
100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 12,349,1971

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H317
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R43
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS RC6308000
HS Code 29224995

 Synthetic Route

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Articles36

More Articles
L-selenomethionine reduces platinum(IV) anticancer model compounds at strikingly faster rates than L-methionine.

Dalton Trans. 43(41) , 15328-36, (2014)

L-Selenomethionine (SeMet), the predominant form of selenium acquired from the diet by humans, has been used as a supplement, and exhibit some important functions like cancer prevention and antioxidat...

Leucine and alpha-ketoisocaproic acid, but not norleucine, stimulate skeletal muscle protein synthesis in neonatal pigs.

J. Nutr. 140(8) , 1418-24, (2010)

The branched-chain amino acid, leucine, acts as a nutrient signal to stimulate protein synthesis in skeletal muscle of young pigs. However, the chemical structure responsible for this effect has not b...

Changes in Serum Amino Acids in Migraine Patients without and with Aura and their Possible Usefulness in the Study of Migraine Pathogenesis.

CNS Neurol. Disord. Drug Targets 14(3) , 345-9, (2015)

Results of several studies suggest that serum amino acids monitoring in migraine might be useful as an objective measurement of the disease status.The aim of the present work was to analyze the profil...

 Synonyms

L-2-Aminohexanoic acid
EINECS 206-321-4
(S)-Norleucine
Norleucine
(S)-2-amino-Hexanoic acid
(S)-(+)-2-Aminohexanoic acid
H-L-NLE-OH
Glycoleucine
H-L-NORLEUCINE
L-Norleucine
(S)-(+)-2-Aminohexanoic acid (S)-2-Aminocaproic acid
(S)-Aminohexanoic acid
(S)-a-Aminocaproic acid
L-2-Amino-hexanoic acid
L-Aminohexanoic acid
Norleucine, L-
(S)-2-Aminohexanoic acid
caprine
H-NLE-OH
H-ACPO(2)-OH
L-2-aminohexanoate
H-AHX(2)-OH
D,L-Norleucine
MFCD00064423
L(+)-Norleucine
(S)-2-aminocaproic acid
N-NORLEUCINE
Top Suppliers:I want be here


  • Nanjing Peptide Biotech Ltd
  • China
  • Product Name: H-Nle-OH
  • Price: ¥Inquiry/10g ¥Inquiry/100g ¥Inquiry/1kg ¥Inquiry/10kg
  • Purity: 98.0%
  • Stocking Period: 7 Day
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Price: ¥770/10 mM * 1 mL in DMSO

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