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China
Product Name: Robotnikinin
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DC Chemicals Limited
China
Product Name: Robotnikinin
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Robotnikinin
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Robotnikinin
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Purity: 98.0%
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1132653-79-2

1132653-79-2 structure

1132653-79-2 structure

Name: Robotnikinin
Chemical Name: Robotnikinin
CAS Number: 1132653-79-2
Molecular Formula: C₂₅H₂₇ClN₂O₄
Molecular Weight: 454.95
Catalog: Signaling Pathways Stem Cell/Wnt Hedgehog
Create Date: 2017-09-16 04:39:41
Modify Date: 2024-01-15 13:40:06
Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo[1][2].

Name	Robotnikinin
Synonyms	R-lactic acid tert-butyl ester bovine dodecapeptide D-lactic acid tert-butyl ester RLCRIVVIRVCR 3-11 disulfide

Description	Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo[1][2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Hedgehog Research Areas >> Inflammation/Immunology
In Vitro	Robotnikinin demonstrates ShhN-binding capacity at concentrations between 1.56 μM and 25 μM, with a KD of 3.1 μM derived from kinetic data[2]. Robotnikinin (50 µM) prevents the ShhN-induced LC3-II increase[3]. Robotnikinin (5 μM) downregulates classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells, suggesting a link between Hh signaling and the NF-κB pathway in MM[4]. RT-PCR[4] Cell Line: NCI-H929 or U266 cells. Concentration: 5 μM. Incubation Time: 48 h. Result: Downregulated classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells.
References	[1]. Manuel Hitzenberger, et al. The Binding Mode of the Sonic Hedgehog Inhibitor Robotnikinin, a Combined Docking and QM/MM MD Study. Front Chem [2]. Benjamin Z Stanton, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5(3):154-6. [3]. Ronald S Petralia, et al. Sonic hedgehog promotes autophagy in hippocampal neurons. Biol Open. 2013 Apr 8;2(5):499-504. [4]. Ke Cai, et al. Targeting the cross-talk between the hedgehog and NF-κB signaling pathways in multiple myeloma. Leuk Lymphoma. 2019 Mar;60(3):772-781.

Molecular Formula	C₂₅H₂₇ClN₂O₄
Molecular Weight	454.95
Exact Mass	454.16600
PSA	84.50000
LogP	4.82300

1132653-78-1 structure

1132653-78-1

~64%

1132653-79-2 structure

1132653-79-2

Literature: PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION Patent: WO2009/132032 A2, 2009 ; Location in patent: Page/Page column 107 ;