181769-57-3

181769-57-3 structure

Name: (Rac)-Calpain Inhibitor XII
Chemical Name: Calpain Inhibitor XII
CAS Number: 181769-57-3
Molecular Formula: C₂₆H₃₄N₄O₅
Molecular Weight: 482.572
Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
Create Date: 2017-09-09 17:34:45
Modify Date: 2025-08-25 09:14:58
(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM), with lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). (Rac)-Calpain Inhibitor XII has been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.

Name	Calpain Inhibitor XII
Synonyms	N-[(benzyloxy)carbonyl]-N-{1,2-dioxo-1-[(pyridin-2-ylmethyl)amino]hexan-3-yl}leucinamide N-[(Benzyloxy)carbonyl]-N-{1,2-dioxo-1-[(2-pyridinylmethyl)amino]-3-hexanyl}leucinamide Carbamic acid, N-[1-[[[1-[1,2-dioxo-2-[(2-pyridinylmethyl)amino]ethyl]butyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester

Description	(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM), with lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). (Rac)-Calpain Inhibitor XII has been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome