181769-57-3
181769-57-3 structure
- Name: (Rac)-Calpain Inhibitor XII
- Chemical Name: Calpain Inhibitor XII
- CAS Number: 181769-57-3
- Molecular Formula: C26H34N4O5
- Molecular Weight: 482.572
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
- Create Date: 2017-09-09 17:34:45
- Modify Date: 2026-07-01 12:36:50
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(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM), with lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). (Rac)-Calpain Inhibitor XII has been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.
| Name | Calpain Inhibitor XII |
|---|---|
| Synonyms |
N-[(benzyloxy)carbonyl]-N-{1,2-dioxo-1-[(pyridin-2-ylmethyl)amino]hexan-3-yl}leucinamide
Z-L-NVA-CONH-CH2-2-PY N-[(Benzyloxy)carbonyl]-N-{1,2-dioxo-1-[(2-pyridinylmethyl)amino]-3-hexanyl}leucinamide CALPAIN INHIBITOR XII Cbamic acid, [3-methyl-1-[[[1-[oxo[(2-pyridinylmethyl)amino]acetyl]butyl]amino]carbonyl]butyl]-, phenylmethyl ester (9CI) Carbamic acid, N-[1-[[[1-[1,2-dioxo-2-[(2-pyridinylmethyl)amino]ethyl]butyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester benzyl N-[1-[[1,2-dioxo-1-(pyridin-2-ylmethylamino)hexan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]cbamate |
| Description | (Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM), with lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). (Rac)-Calpain Inhibitor XII has been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury. |
|---|---|
| Related Catalog |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C26H34N4O5 |
| Molecular Weight | 482.572 |
| Exact Mass | 482.252930 |
| PSA | 126.49000 |
| LogP | 3.17 |
| Index of Refraction | 1.548 |