(Rac)-Calpain Inhibitor XII

Modify Date: 2024-01-11 08:51:25

(Rac)-Calpain Inhibitor XII Structure
(Rac)-Calpain Inhibitor XII structure
Common Name (Rac)-Calpain Inhibitor XII
CAS Number 181769-57-3 Molecular Weight 482.572
Density 1.2±0.1 g/cm3 Boiling Point N/A
Molecular Formula C26H34N4O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (Rac)-Calpain Inhibitor XII


(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM), with lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). (Rac)-Calpain Inhibitor XII has been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.

 Names

Name Calpain Inhibitor XII
Synonym More Synonyms

 (Rac)-Calpain Inhibitor XII Biological Activity

Description (Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM), with lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). (Rac)-Calpain Inhibitor XII has been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.
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 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Molecular Formula C26H34N4O5
Molecular Weight 482.572
Exact Mass 482.252930
PSA 126.49000
LogP 3.17
Index of Refraction 1.548

 Synonyms

N-[(benzyloxy)carbonyl]-N-{1,2-dioxo-1-[(pyridin-2-ylmethyl)amino]hexan-3-yl}leucinamide
N-[(Benzyloxy)carbonyl]-N-{1,2-dioxo-1-[(2-pyridinylmethyl)amino]-3-hexanyl}leucinamide
Carbamic acid, N-[1-[[[1-[1,2-dioxo-2-[(2-pyridinylmethyl)amino]ethyl]butyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester
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