124904-93-4

124904-93-4 structure

Name: Ganirelix
Chemical Name: ganirelix
CAS Number: 124904-93-4
Molecular Formula: C₈₀H₁₁₃ClN₁₈O₁₃
Molecular Weight: 1570.32000
Catalog: Signaling Pathways GPCR/G Protein GNRH Receptor
Create Date: 2018-08-19 11:08:14
Modify Date: 2024-01-02 12:10:15
Ganirelix is a competitive and selective gonadotropin releasing hormone (GnRH) antagonist. Ganirelix prevents endogenous GnRH from inducing luteinising hormone (LH) and follicle stimulating hormone relea[1].

Name	ganirelix

Description	Ganirelix is a competitive and selective gonadotropin releasing hormone (GnRH) antagonist. Ganirelix prevents endogenous GnRH from inducing luteinising hormone (LH) and follicle stimulating hormone relea[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GNRH Receptor Research Areas >> Metabolic Disease
In Vivo	Ganirelix (0.1 mg/kg; s.c.; daily for 14 d) reduces luteinising hormone levels in female rats[2]. Animal Model: Female Sprague-Dawley rats, weighing 225–300 mg[2] Dosage: 0.1 mg/kg Administration: Subcutaneous injection, daily for 14 d Result: Reduced luteinising hormone levels.
References	[1]. Gillies PS, et al. Ganirelix. Drugs. 2000 Jan;59(1):107-11; discussion 112-3. [2]. Russo A, et al. Effects of the gonadotropin-releasing hormone antagonist ganirelix on normal micturition and prostaglandin E(2)-induced detrusor overactivity in conscious female rats. Eur Urol. 2011 May;59(5):868-74.

123246-29-7	124904-93-4
129311-55-3	208599-57-9