Ganirelix

Modify Date: 2025-08-25 10:50:06

Ganirelix Structure
Ganirelix structure
Common Name Ganirelix
CAS Number 124904-93-4 Molecular Weight 1570.32000
Density 1.31 g/cm3 Boiling Point N/A
Molecular Formula C80H113ClN18O13 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ganirelix


Ganirelix is a competitive and selective gonadotropin releasing hormone (GnRH) antagonist. Ganirelix prevents endogenous GnRH from inducing luteinising hormone (LH) and follicle stimulating hormone relea[1].

 Names

Name ganirelix

 Ganirelix Biological Activity

Description Ganirelix is a competitive and selective gonadotropin releasing hormone (GnRH) antagonist. Ganirelix prevents endogenous GnRH from inducing luteinising hormone (LH) and follicle stimulating hormone relea[1].
Related Catalog
In Vivo Ganirelix (0.1 mg/kg; s.c.; daily for 14 d) reduces luteinising hormone levels in female rats[2]. Animal Model: Female Sprague-Dawley rats, weighing 225–300 mg[2] Dosage: 0.1 mg/kg Administration: Subcutaneous injection, daily for 14 d Result: Reduced luteinising hormone levels.
References

[1]. Gillies PS, et al. Ganirelix. Drugs. 2000 Jan;59(1):107-11; discussion 112-3.

[2]. Russo A, et al. Effects of the gonadotropin-releasing hormone antagonist ganirelix on normal micturition and prostaglandin E(2)-induced detrusor overactivity in conscious female rats. Eur Urol. 2011 May;59(5):868-74.

 Chemical & Physical Properties

Density 1.31 g/cm3
Molecular Formula C80H113ClN18O13
Molecular Weight 1570.32000
Exact Mass 1568.84000
PSA 451.49000
LogP 7.99260
InChIKey GJNXBNATEDXMAK-PFLSVRRQSA-N
SMILES CCNC(=NCCCCC(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1cccnc1)NC(=O)C(Cc1ccc(Cl)cc1)NC(=O)C(Cc1ccc2ccccc2c1)NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCCN=C(NCC)NCC)C(=O)N1CCCC1C(=O)NC(C)C(N)=O)NCC
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