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1309-37-1

1309-37-1 structure
1309-37-1 structure
  • Name: Ferric oxide
  • Chemical Name: ferric oxide
  • CAS Number: 1309-37-1
  • Molecular Formula: Fe2O3
  • Molecular Weight: 159.69
  • Catalog: Inorganic chemical industry Oxides and peroxides Metal oxide
  • Create Date: 2018-02-04 08:00:00
  • Modify Date: 2024-01-02 06:12:15
  • Ferric oxide, red can be used as an excipient, such as colorant. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].
Name ferric oxide
Synonyms MFCD00748135
Iron(III) oxide,-100 mesh,(trace metal basis)
Iron oxide in
Ferric oxide
Iron oxide(II,III)
Ferric sesquioxide
EINECS 215-168-2
Iron(III) oxide
Description Ferric oxide, red can be used as an excipient, such as colorant. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].
Related Catalog
References

[1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

Density 5.24
Melting Point 1538ºC
Molecular Formula Fe2O3
Molecular Weight 159.69
Flash Point >230°F
Exact Mass 159.854630
PSA 43.37000
Stability Stable.
Water Solubility INSOLUBLE

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NO7400000
CHEMICAL NAME :
Iron(III) oxide
CAS REGISTRY NUMBER :
1309-37-1
LAST UPDATED :
199712
DATA ITEMS CITED :
44
MOLECULAR FORMULA :
Fe2-O3
MOLECULAR WEIGHT :
159.70
WISWESSER LINE NOTATION :
FE2 O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 ug/m3/24H/61D-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 50(7),73,1985 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
135 mg/kg
REFERENCE :
PBPHAW Progress in Biochemical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1965- Volume(issue)/page/year: 14,47,1978 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3, Inhalable dust DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal NO EVIDENCE IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,29,1972 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,29,1972 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,216,1987 TOXICOLOGY REVIEW ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7. Volume(issue)/page/year: 78,99,1972 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:NUISANCE PARTICULATES DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,27,1973 OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Gen Indu):8H TWA 5 mg/m3, respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Construc):8H TWA 5 mg/m3, respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Shipyard):8H TWA 5 mg/m3, respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 3 ppm (5 mg/m3) (fume) JAN 1993 OEL-AUSTRALIA:TWA 5 mg/m3 (fume) JAN 1993 OEL-BELGIUM:TWA 2 ppm (5 mg/m3) (fume) JAN 1993 OEL-DENMARK:TWA 3.5 mg/m3 (fume) JAN 1993 OEL-FINLAND:TWA 5 ppm (fume) JAN 1993 OEL-FRANCE:TWA 5 mg/m3 (fume) JAN 1993 OEL-GERMANY:TWA 6 mg/m3 (fume) JAN 1993 OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 5 mg/m3 (fume) JAN 1993 OEL-THE PHILIPPINES:TWA 10 mg/m3 (fume) JAN 1993 OEL-POLAND:TWA 5 mg/m3 (fume) JAN 1993 OEL-SWEDEN:TWA 3.5 mg/m3 (fume) JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (5 mg/m3) (fume) JAN 1993 OEL-THAILAND:TWA 10 mg/m3 (fume) JAN 1993 OEL-TURKEY:TWA 10 mg/m3 (fume) JAN 1993 OEL-UNITED KINGDOM:TWA 10 mg/m3 (total dust) JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3 (resp. dust) JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3;STEL 10 mg/m3 (fume) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO IRON OXIDE, dust and fume (as Fe)-air:10H TWA 5 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1463 No. of Facilities: 41132 (estimated) No. of Industries: 265 No. of Occupations: 153 No. of Employees: 483117 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1463 No. of Facilities: 62557 (estimated) No. of Industries: 308 No. of Occupations: 185 No. of Employees: 965275 (estimated) No. of Female Employees: 139397 (estimated)
Symbol GHS02 GHS05
GHS02, GHS05
Signal Word Danger
Hazard Statements H225-H318
Precautionary Statements P210-P280-P305 + P351 + P338 + P310-P370 + P378-P403 + P235
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26
RIDADR UN 1376
WGK Germany -
RTECS NO7400000
HS Code 2821100000
HS Code 2821100000

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