69120-07-6

69120-07-6 structure

Name: Moracin D
Chemical Name: 7-(6-Hydroxy-1-benzofuran-2-yl)-2,2-dimethyl-2H-chromen-5-ol
CAS Number: 69120-07-6
Molecular Formula: C₁₉H₁₆O₄
Molecular Weight: 308.328
Catalog: Natural product Phenols
Create Date: 2018-07-23 08:52:07
Modify Date: 2024-01-02 22:20:32
Moracin D is a flavonoid that can be isolated from Morus alba. Moracin D induces cell apoptosis and shows hypoglycemic, antiadipogenic, antifungal and antitumor effects. Moracin D can be used for fungal infection and breast cancer research[1][2][3].

Name	7-(6-Hydroxy-1-benzofuran-2-yl)-2,2-dimethyl-2H-chromen-5-ol
Synonyms	2H-1-Benzopyran-4-ol, 7-(6-hydroxy-2-benzofuranyl)-2,2-dimethyl- 7-(6-Hydroxy-1-benzofuran-2-yl)-2,2-dimethyl-2H-chromen-4-ol 7-(6-Hydroxy-1-benzofuran-2-yl)-2,2-dimethyl-2H-chromen-5-ol 2H-1-Benzopyran-5-ol, 7-(6-hydroxy-2-benzofuranyl)-2,2-dimethyl-

Description	Moracin D is a flavonoid that can be isolated from Morus alba. Moracin D induces cell apoptosis and shows hypoglycemic, antiadipogenic, antifungal and antitumor effects. Moracin D can be used for fungal infection and breast cancer research[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Moracin D (0，3.75，7.5，15，30 μM；24 小时) 降低 DU145 和 PC3 细胞的活力，IC50 分别为 15 和 24.8 μM[1]。 Moracin D (0，7.5，15 μM；24 小时) 增加 DU145 和 PC3 前列腺癌细胞的 sub G1 细胞群[1]。 Moracin D (0，7.5，15 μM；24 小时) 抑制抗凋亡蛋白的表达水平，增加 DU145 细胞的 TUNEL 阳性细胞数，诱导 DU145 细胞凋亡[1]。 Moracin D 对玫瑰镰刀菌、赤霉病菌、茄病菌、赤霉病菌、森氏刺头菌、黑蔷薇菌和麻斑病菌有抑菌活性，MIC 值分别为 7-14，28-56，112，7-14，56-112，<3.5 和 14-28 μg/mL[2]。 Cell Viability Assay[1] Cell Line: DU145 and PC3 cell lines Concentration: 0, 3.75, 7.5, 15 and 30 μM Incubation Time: 24 hours Result: Significantly and dose-dependently reduced the viability of DU145 and PC3 cells. Western Blot Analysis[1] Cell Line: DU145 cell line Concentration: 0, 7.5 and 15 μM Incubation Time: 24 hours Result: Cleaved PARP, activated PPAR-γ/PKC-δ, and decreased the level of Pro-caspase 3, Bcl-2, Bcl-xL, PKC-α and phosphorylation of NF-κB, ERK, AKT in DU145 cells.
References	[1]. Yoon JS, et al. Moracin D induces apoptosis in prostate cancer cells via activation of PPAR gamma/PKC delta and inhibition of PKC alpha. Phytother Res. 2021 Dec;35(12):6944-6953. [2]. Takasugi Mitsuo, et al. MORACIN C AND D, NEW PHYTOALEXINS FROM DISEASED MULBERRY. CSJ Journals. 1978, Vol.7, No.11. [3]. Hwang SM, et al. Inhibition of Wnt3a/FOXM1/β-Catenin Axis and Activation of GSK3β and Caspases are Critically Involved in Apoptotic Effect of Moracin D in Breast Cancers. Int J Mol Sci. 2018 Sep 10;19(9):2681.

Density	1.3±0.1 g/cm3
Boiling Point	419.1±45.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₆O₄
Molecular Weight	308.328
Flash Point	207.3±28.7 °C
Exact Mass	308.104858
PSA	62.83000
LogP	5.05
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.665

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