124689-65-2
124689-65-2 structure
- Name: Cryptophycin 1
- Chemical Name: (3S,6R,10R,13E,16S)-10-[(3-chloro-4-methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone
- CAS Number: 124689-65-2
- Molecular Formula: C35H43ClN2O8
- Molecular Weight: 655.17800
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2016-11-24 20:58:05
- Modify Date: 2025-08-25 08:38:49
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Cryptophycin 1 is a potent cytotoxic antimicrotubule agent which is isolated from Nostoc sp. Cryptophycin 1 can induce cells apoptosis, and exhibits antitumor activity and exceptional antiproliferative potency[1][2][3].
| Name | (3S,6R,10R,13E,16S)-10-[(3-chloro-4-methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone |
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| Synonyms |
10-((3-Chloro-4-methoxyphenyl)methyl)-6-methyl-3-(2-methylpropyl)-16-(1-(3-phenyloxiranyl)ethyl)-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone
CRYPTOPHYCIN A C35H43ClN2O8 1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone,10-((3-chloro-4-methoxyphenyl)methyl)-6-methyl-3-(2-methylpropyl)-16-(1-(3-phenyloxiranyl)ethyl) cryptophycin cryptophycin-1 |
| Description | Cryptophycin 1 is a potent cytotoxic antimicrotubule agent which is isolated from Nostoc sp. Cryptophycin 1 can induce cells apoptosis, and exhibits antitumor activity and exceptional antiproliferative potency[1][2][3]. |
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| Related Catalog | |
| In Vitro | Cryptophycin 1 (50 pM) rapidly causes morphological changes consistent with the induction of apoptosis in SKOV3 and MDA-MB-435 cells[1]. Cryptophycin 1 (50 pM; 12-24 h) causes an accumulation of MDA-MB-435 cells in G2/M[1]. Cryptophycin 1 (100 nM; 1-7 min) markedly reduces the rates and extents of microtubule shortening and growing events and dramatically increases the duration of phases of attenuation or pause[2]. Apoptosis Analysis[1] Cell Line: SKOV3 cells Concentration: 50 pM Incubation Time: 4 hours Result: Caused rapid cell shrinkage, loss of the normal elliptical spheroid shape and the formation of membrane blebs. Cell Cycle Analysis[1] Cell Line: MDA-MB-435 cells Concentration: 50 pM Incubation Time: 12, 18, 24 hours Result: A doubling in the number of cells in G2/M at 12 hr. Still a large number of cells (58%) in G2/M at 18 hr. |
| In Vivo | Cryptophycin 1 (i.v.) exhibits anti-tumor activity in mice[3]. |
| References |
| Density | 1.171g/cm3 |
|---|---|
| Boiling Point | 889.4ºC at 760 mmHg |
| Molecular Formula | C35H43ClN2O8 |
| Molecular Weight | 655.17800 |
| Flash Point | 491.7ºC |
| Exact Mass | 654.27100 |
| PSA | 139.54000 |
| LogP | 5.28580 |
| Vapour Pressure | 2.92E-32mmHg at 25°C |
| Index of Refraction | 1.526 |
| RIDADR | UN 3172 |
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| Packaging Group | III |
| Hazard Class | 6.1(b) |