DC Chemicals Limited
China
Product Name: Flazin
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

100041-05-2

100041-05-2 structure

Name: Flazin
Chemical Name: 1-[5-(hydroxymethyl)furan-2-yl]-9H-pyrido[3,4-b]indole-3-carboxylic acid
CAS Number: 100041-05-2
Molecular Formula: C₁₇H₁₂N₂O₄
Molecular Weight: 308.28800
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2016-05-17 16:48:47
Modify Date: 2025-08-26 10:33:18
Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO-), with an IC50 value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC50 value of 71.99 μM for ONOO-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor[1][2][3].

Name	1-[5-(hydroxymethyl)furan-2-yl]-9H-pyrido[3,4-b]indole-3-carboxylic acid
Synonyms	Flazine 3-carboxylperlolyrine Flazin 9H-Pyrido[3,4-b]indole-3-carboxylic acid,1-[5-(hydroxymethyl)-2-furanyl]

Description	Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO-), with an IC50 value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC50 value of 71.99 μM for ONOO-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase Research Areas >> Neurological Disease
Target	IC50: 85.31 μM (BSA), 0.51 mM (XOD)[1][2] EC50: 71.99 μM (ONOO-)[1]
In Vitro	Flazin significantly decreases cellular triglyceride (TG) by 12.0-22.4% compared with modeling groups and improved the TG and free fatty acid profile[2]. Flazin efficiently reduces both cellular neutral lipid content by 17.4-53.9% and lipid droplets size by 10.0-35.3%[2]. Flazin exhibits xanthine oxidase inhibitory with an IC50 of 0.51 mM[3].
References	[1]. Seong SH, et al. Discovery of Flazin, an Alkaloid Isolated from Cherry Tomato Juice, As a Novel Non-Enzymatic Protein Glycation Inhibitor viain Vitro and in Silico Studies. J Agric Food Chem. 2021 Mar 31;69(12):3647-3657. [2]. Wu X, et al. Flazin as a Lipid Droplet Regulator against Lipid Disorders. Nutrients. 2022 Apr 3;14(7):1501. [3]. Li H, et al. Effect of Soy Sauce on Serum Uric Acid Levels in Hyperuricemic Rats and Identification of Flazin as a Potent Xanthine Oxidase Inhibitor. J Agric Food Chem. 2016 Jun 15;64(23):4725-34.

Density	1.513g/cm3
Boiling Point	657.1ºC at 760mmHg
Molecular Formula	C₁₇H₁₂N₂O₄
Molecular Weight	308.28800
Flash Point	351.2ºC
Exact Mass	308.08000
PSA	99.35000
LogP	3.16660
Vapour Pressure	3.69E-18mmHg at 25°C
Index of Refraction	1.771

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