158146-85-1

158146-85-1 structure
158146-85-1 structure
  • Name: TAK-603
  • Chemical Name: ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate
  • CAS Number: 158146-85-1
  • Molecular Formula: C25H26N4O6
  • Molecular Weight: 478.50
  • Create Date: 2016-02-18 15:11:32
  • Modify Date: 2025-08-25 10:48:49
  • TAK-603 is a potent and orally active antirheumatic agent. TAK-603 inhibits Thl-type cytokine production. TAK-603 has the potential for the research of adjuvant arthritis[1][2].

Name ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate
Synonyms 3-Quinolinecarboxylic acid,4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1H-1,2,4-triazol-1-ylmethyl)-,ethyl ester
ethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate
ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1H-1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate
6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylic acid ethyl ester
ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(4H-1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate
Ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1H-1,2,4-triazol-1-ylmethyl)-3-quinolinecarboxylate
4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylic acid ethyl ester
Description TAK-603 is a potent and orally active antirheumatic agent. TAK-603 inhibits Thl-type cytokine production. TAK-603 has the potential for the research of adjuvant arthritis[1][2].
Related Catalog
In Vitro TAK-603 (0, 1, 10 µM; 48 h) 抑制同种异体反应性和 OVA 反应性 BALB/c 小鼠 T 细胞系中的 IFN-γ 的产生,但对 IL-4 产生几乎没有影响 [2].
In Vivo TAK-603 (6.25 mg/kg;口服;每天) 减少关节炎病变和脾脏中 Thl-型细胞因子的产生[2]。 Animal Model: AA rats[2] Dosage: 6.25 mg/kg Administration: P.o.; daily Result: Inhibited arthritic paw swelling with the inhibition rate of 65% and the IFN-y mRNA expression in the arthritic joint was significantly reduced.
References

[1]. Mizuno M, et al. Syntheses of metabolites of ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate (TAK-603). Tetrahedron, 2006, 62(37), 8707–8714.

[2]. Ohta Y, et al. TAK-603 selectively suppresses Th1-type cytokine production and inhibits the progression of adjuvant arthritis. Immunology. 1997 Sep;92(1):75-83.  

Density 1.29g/cm3
Boiling Point 640.7ºC at 760 mmHg
Molecular Formula C25H26N4O6
Molecular Weight 478.50
Flash Point 341.3ºC
Exact Mass 478.18500
PSA 106.82000
LogP 3.75270
Vapour Pressure 2.59E-16mmHg at 25°C
Index of Refraction 1.604
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