865200-20-0

865200-20-0 structure

Name: Giripladib
Chemical Name: Giripladib
CAS Number: 865200-20-0
Molecular Formula: C₄₁H₃₆ClF₃N₂O₄S
Molecular Weight: 745.25
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
Create Date: 2018-03-06 08:00:00
Modify Date: 2024-01-09 13:50:25
Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A2 (cPLA2). Giripladib can be used for osteoarthritis and breast cancer research[1][2].

Name	Giripladib
Synonyms	PLA 695 4-[3-[1-benzhydryl-5-chloro-2-[2-[[2-(trifluoromethyl)phenyl]methylsulfonylamino]ethyl]indol-3-yl]propyl]benzoic acid

Description	Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A2 (cPLA2). Giripladib can be used for osteoarthritis and breast cancer research[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Inflammation/Immunology
Target	cPLA2α
References	[1]. Kokotos G, et al. Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo. J Med Chem. 2014 Sep 25;57(18):7523-35. [2]. Liu S, et al. A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties. J Hematol Oncol. 2021 Oct 29;14(1):178.