519055-62-0

519055-62-0 structure

Name: Tasisulam
Chemical Name: N-(5-bromothiophen-2-yl)sulfonyl-2,4-dichlorobenzamide
CAS Number: 519055-62-0
Molecular Formula: C₁₁H₆BrCl₂NO₃S₂
Molecular Weight: 415.110
Catalog: Biochemical Inhibitor Apoptosis Caspase activator
Create Date: 2018-09-12 21:40:35
Modify Date: 2024-01-03 13:12:50
Tasisulam is a small molecule antitumor agent that inhibits mitotic progression and induces vascular normalization. Tasisulam induces apoptosis via the intrinsic pathway[1].

Name	N-(5-bromothiophen-2-yl)sulfonyl-2,4-dichlorobenzamide
Synonyms	N-[(5-Bromo-2-thienyl)sulfonyl]-2,4-dichlorobenzamide Benzamide, N-[(5-bromo-2-thienyl)sulfonyl]-2,4-dichloro- 5-Bromo-N-(2,4-dichlorobenzoyl)-2-thiophenesulfonamide Tasisulam cc-591 UNII-1YC4W9MSLJ T5SJ BSWMVR BG DG&& EE LY573636

Description	Tasisulam is a small molecule antitumor agent that inhibits mitotic progression and induces vascular normalization. Tasisulam induces apoptosis via the intrinsic pathway[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	Tasisulam (200 μM-200 nM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC50s is 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively[1]. Tasisulam (25, 50 μM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation[1]. Tasisulam (200 μM-200 nM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models[1]. Cell Proliferation Assay[1] Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 μM-200 nM Incubation Time: 48 hours Result: Induced an antiproliferative response across a wide range of tumor histologies with EC50s are 10 μM and 25 μM, respectively. Cell Cycle Analysis[1] Cell Line: Calu-6 and A-375 cell lines Concentration: 25, 50 μM Incubation Time: 72 hours Result: Induced a concentration-dependent increase in 4N DNA and G2-M accumulation. Apoptosis Analysis[1] Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 μM-200 nM Incubation Time: 48 hours Result: Induced apoptosis in a broad range of in vitro cancer cell models.
References	[1]. Meier T, et al. Tasisulam sodium, an antitumor agent that inhibits mitotic progression and induces vascular normalization. Mol Cancer Ther. 2011 Nov;10(11):2168-78.

Density	1.8±0.1 g/cm3
Molecular Formula	C₁₁H₆BrCl₂NO₃S₂
Molecular Weight	415.110
Exact Mass	412.834930
PSA	99.86000
LogP	3.94
Index of Refraction	1.657
Storage condition	-20℃

HS Code	2934999090

50-84-0

1152981-12-8

~99%

519055-62-0

Literature: Kosal, Andrew D.; Wilson, Erin E.; Ashfeld, Brandon L. Chemistry--A European Journal, 2012 , vol. 18, # 45 p. 14444 - 14453,10 Title/Abstract Full Text Show Details Kosal, Andrew D.; Wilson, Erin E.; Ashfeld, Brandon L. Chemistry - A European Journal, 2012 , vol. 18, # 45 p. 14444 - 14453

53595-65-6

89-75-8

~97%

519055-62-0

Literature: Yates, Matthew H.; Kallman, Neil J.; Ley, Christopher P.; Wei, Jeffrey N. Organic Process Research and Development, 2009 , vol. 13, # 2 p. 255 - 262

53595-65-6

50-84-0

519055-62-0

Literature: Mader, Mary M.; Shih, Chuan; Considine, Eileen; De Dios, Alfonso; Grossman, Cora Sue; Hipskind, Philip A.; Lin, Ho-Shen; Lobb, Karen L.; Lopez, Beatriz; Lopez, Jose E.; Cabrejas, Luisa M. Martin; Richett, Michael E.; White, Wesley T.; Cheung, Yiu-Yin; Huang, Zhongping; Reilly, John E.; Dinn, Sean R. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 617 - 620

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%