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54149-17-6

54149-17-6 structure

54149-17-6 structure

Name: m-PEG2-Br
Chemical Name: 1-Bromo-2-(2-methoxyethoxy)ethane
CAS Number: 54149-17-6
Molecular Formula: C₅H₁₁BrO₂
Molecular Weight: 183.044
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-12-25 19:38:07
Modify Date: 2026-07-12 21:07:17
m-PEG2-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1-Bromo-2-(2-methoxyethoxy)ethane
Synonyms	mPEG2-Br 1-Bromo-(2-methoxyethoxy)ethane MFCD00000238 CAS_54-6 Bromo-PEG2-methoxy DKSI138 1-Bromo-2-(2-methoxyethoxy)ethane ( with NaCO) EINECS 259-000-6 DK815 1-(2-Bromoethoxy)-2-methoxyethane 2-(2-Methoxyethoxy)ethyl bromide 1-Bromo-2-(2-methoxyethoxy)ethane ( with Na2CO3) 1-Bromo-2-(2-Methoxyethoxy)Ethane, Stab. With Sodium Cbonate 1-BROMO-(2-METHOXYETHOXY)ETHANE Ethane,1-bromo-2-(2-methoxyethoxy) 1-Bromo-(2-methoxyethoxy)ethane (stabilised with sodium cbonate) 2-Bromoethyl 2-methoxyethyl ether 1-Bromo-2-(2-methoxyethoxy)ethane, . , stab. with sodium cbonate 1-bromo-3,6-dioxahtane Ethane, 1-(2-bromoethoxy)-2-methoxy DKFELEX0212 1-Bromo-2-(2-methoxyethoxy)ethane ( with Na2CO3) > 1-BROMO-2-(2-METHOXYETHOXY)ETHANE MONO METHOXY PEG BROMIDE m-PEG2-Br,( with Na2CO3) Methyl-PEG2-bromide 1-BROMO-2-(2-METHOXYETHOXY)ETHANE WITH SODIUM CBONATE Ethylene Glycol 2-Bromoethyl Methyl Ether 1-Bromo-2-(2-methoxyethoxy)ethane, with sodium cbonate 1-BROMO-2-(2-METHOXYETHOXY)ETHANE, . , STAB. WITH SOD

Description	m-PEG2-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density	1.3±0.1 g/cm3
Boiling Point	184.4±15.0 °C at 760 mmHg
Molecular Formula	C₅H₁₁BrO₂
Molecular Weight	183.044
Flash Point	73.9±0.0 °C
Exact Mass	181.994232
PSA	18.46000
LogP	0.54
Vapour Pressure	1.0±0.3 mmHg at 25°C
Index of Refraction	1.445
Storage condition	Refrigerator (+4°C)

Personal Protective Equipment	Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
Risk Phrases	36/37/38
Safety Phrases	S24/25
WGK Germany	3
HS Code	2909199090

111-77-3 structure

111-77-3

~91%

54149-17-6 structure

54149-17-6

Literature: Wu, Zhongkui; Wu, Sanxie; Liang, Yingqiu Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2003 , vol. 59, # 7 p. 1631 - 1641

50586-80-6 structure

50586-80-6

~97%

54149-17-6 structure

54149-17-6

Literature: Northrop, Brian H.; Gloeckner, Andreas; Stang, Peter J. Journal of Organic Chemistry, 2008 , vol. 73, # 5 p. 1787 - 1794

HS Code	2909199090
Summary	2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

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