m-PEG2-Br

Modify Date: 2025-08-23 15:48:25

m-PEG2-Br Structure
m-PEG2-Br structure
Common Name m-PEG2-Br
CAS Number 54149-17-6 Molecular Weight 183.044
Density 1.3±0.1 g/cm3 Boiling Point 184.4±15.0 °C at 760 mmHg
Molecular Formula C5H11BrO2 Melting Point N/A
MSDS Chinese USA Flash Point 73.9±0.0 °C

 Use of m-PEG2-Br


m-PEG2-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 1-Bromo-2-(2-methoxyethoxy)ethane
Synonym More Synonyms

 m-PEG2-Br Biological Activity

Description m-PEG2-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 184.4±15.0 °C at 760 mmHg
Molecular Formula C5H11BrO2
Molecular Weight 183.044
Flash Point 73.9±0.0 °C
Exact Mass 181.994232
PSA 18.46000
LogP 0.54
Vapour Pressure 1.0±0.3 mmHg at 25°C
Index of Refraction 1.445
Storage condition Refrigerator (+4°C)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
Risk Phrases 36/37/38
Safety Phrases S24/25
WGK Germany 3
HS Code 2909199090

 Synthetic Route

~91%

m-PEG2-Br Structure

m-PEG2-Br

CAS#:54149-17-6

Literature: Wu, Zhongkui; Wu, Sanxie; Liang, Yingqiu Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2003 , vol. 59, # 7 p. 1631 - 1641

~97%

m-PEG2-Br Structure

m-PEG2-Br

CAS#:54149-17-6

Literature: Northrop, Brian H.; Gloeckner, Andreas; Stang, Peter J. Journal of Organic Chemistry, 2008 , vol. 73, # 5 p. 1787 - 1794

 Customs

HS Code 2909199090
Summary 2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

 Articles3

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Anal. Chem. 69(7) , 1370-9, (1997)

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Molecular engineering of photoremovable protecting groups for two-photon uncaging.

Angew. Chem. Int. Ed. Engl. 47(49) , 9525-9, (2008)

Effect of charge density on energy-transfer properties of cationic conjugated polymers. Pu K-Y, et al.

Adv. Funct. Mater. 18(8) , 1321-1328

 Synonyms

1-Bromo-(2-methoxyethoxy)ethane
1-Bromo-2-(2-methoxyethoxy)ethane
EINECS 259-000-6
MFCD00000238
1-(2-Bromoethoxy)-2-methoxyethane
Ethane, 1-bromo-2-(2-methoxyethoxy)-
Ethane, 1-(2-bromoethoxy)-2-methoxy-
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