66018-41-5

66018-41-5 structure

Name: 5,6,7,15-tetrahydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaen-13-one
Chemical Name: 5,6,7,15-tetrahydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaen-13-one
CAS Number: 66018-41-5
Molecular Formula: C₁₉H₂₄O₇
Molecular Weight: 364.39000
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2016-03-01 23:51:14
Modify Date: 2025-08-27 12:09:37
LL-Z1640-4 is a potent p38/JNK signaling inhibitor. LL-Z1640-4 significantly diminishes p38 and JNK activation in HCC cells transfected with MLK4 siRNA. LL-Z1640-4 markedly attenuates ROS production induced by MLK4 knockdown. LL-Z1640-4 significantly reduces the apoptotic cells in HCC cells transfected with siMLK4[1][2].

Name	5,6,7,15-tetrahydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaen-13-one
Synonyms	Antibiotic LL Z1640-4

Description	LL-Z1640-4 is a potent p38/JNK signaling inhibitor. LL-Z1640-4 significantly diminishes p38 and JNK activation in HCC cells transfected with MLK4 siRNA. LL-Z1640-4 markedly attenuates ROS production induced by MLK4 knockdown. LL-Z1640-4 significantly reduces the apoptotic cells in HCC cells transfected with siMLK4[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Signaling Pathways >> MAPK/ERK Pathway >> JNK
In Vitro	LL-Z1640-4 markedly restores the number of cells in migration and invasion decreased by siMLK4, and significantly up-regulates expression of MMP2 and Vimentin[2].
References	[1]. Ellestad George A, et al. New zearalenone related macrolides and isocoumarins from an unidentified fungus. The Journal of Organic Chemistry, 1978,43(12):2339–2343. [2]. Li Y, Zuo H, Wang H, Hu A. Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling. Biomed Pharmacother. 2019 Aug;116:108749.

Precursor 2
1403608-16-1 1403608-13-8
DownStream 0