53319-52-1

53319-52-1 structure

Name: Isogosferol
Chemical Name: 9-(2-hydroxy-3-methylbut-3-enoxy)furo[3,2-g]chromen-7-one
CAS Number: 53319-52-1
Molecular Formula: C₁₆H₁₄O₅
Molecular Weight: 286.279
Catalog: Natural product Coumarin
Create Date: 2016-02-03 20:54:30
Modify Date: 2025-08-20 17:54:08
Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2[1].

Name	9-(2-hydroxy-3-methylbut-3-enoxy)furo[3,2-g]chromen-7-one
Synonyms	9-[(2-Hydroxy-3-methyl-3-buten-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one 9-((2-Hydroxy-3-methyl-3-butenyl)oxy)-7H-furo(3,2-g)(1)benzopyran-7-one rtuprhihxsawdp-uhfffaoysa 7H-Furo[3,2-g][1]benzopyran-7-one, 9-[[(2S)-2-hydroxy-3-methyl-3-buten-1-yl]oxy]- 9-[(2-Hydroxy-3-methylbut-3-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one 9-{[(2S)-2-Hydroxy-3-methyl-3-buten-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one 7H-Furo(3,2-g)(1)benzopyran-7-one, 9-((2-hydroxy-3-methyl-3-butenyl)oxy)- 7H-Furo[3,2-g][1]benzopyran-7-one, 9-[(2-hydroxy-3-methyl-3-buten-1-yl)oxy]-

Description	Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Isogosferol (100, 200 µM; 1+16 h) 降低 RAW 264.7 细胞中 LPS (HY-D1056) 刺激的 NO 表达[1]。 Isogosferol (0, 25, 50, 100, 200 µM; 1+16 h) 以剂量依赖性方式降低 LPS 刺激的 iNOS、COX-2 蛋白表达[1]。 Isogosferol (0, 25, 50, 100, 200 µM; 1+1 h) 以剂量依赖性方式降低 LPS 刺激的 NF-κB 和 pERK1/2 表达[1]。 Isogosferol (50, 100, 200 µM µM; 1+16 h) 减少 LPS 刺激的促炎细胞因子 IL-1β 的释放[1]。 Cell Viability Assay[1] Cell Line: RAW 264.7 cells Concentration: 100, 200 µM (stimulated with LPS (1 µg/mL)) Incubation Time: 1+16 Result: Remarkably down-regulated the LPS-stimulated NO expression with an IC50 of 148 μM and shows no effect on cell viability. Western Blot Analysis[1] Cell Line: 0, 25, 50, 100, 200 µM Concentration: 1+16 Incubation Time: 1+16 Result: Decreased the expression of iNOS, COX-2 protein in a dose-dependent manner.
References	[1]. Song HY, et al. Anti-Inflammatory Activities of Isogosferol, a Furanocoumarin Isolated from Citrus junos Seed Shells through Bioactivity-Guided Fractionation. Molecules. 2019 Nov 12;24(22):4088.

Hazard Codes	Xi