CVT 10216
Modify Date: 2024-01-02 18:13:09
CVT 10216 structure
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Common Name | CVT 10216 | ||
|---|---|---|---|---|
| CAS Number | 1005334-57-5 | Molecular Weight | 465.475 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 714.2±70.0 °C at 760 mmHg | |
| Molecular Formula | C24H19NO7S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 385.8±35.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of CVT 10216CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC50 of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM. CVT-10216 can reduces excessive alcohol drinking in alcohol-preferring rats and exhibits anxiolytic effects[1]. |
| Name | 3-[[3-[4-(methanesulfonamido)phenyl]-4-oxochromen-7-yl]oxymethyl]benzoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC50 of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM. CVT-10216 can reduces excessive alcohol drinking in alcohol-preferring rats and exhibits anxiolytic effects[1]. |
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| Related Catalog | |
| Target |
IC50: 29 nM (ALDH-2)[1] |
| In Vivo | CVT-10216 (intraperitoneal injection; 3.75, 7.5, or 15 mg/kg) exhibits a increase in social interaction as a dose-dependent manner, punctuated by a 2-fold increase in social interaction after 15 mg/kg in Fawn-Hooded rats[1]. CVT-10216 (intraperitoneal injection; 3.75 or 15 mg/kg) are determined 5 h into the third withdrawal.It has the anxiolytic effect of 15 mg/kg CVT-10216 in this model, but has no significant effects on locomotor activity[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 714.2±70.0 °C at 760 mmHg |
| Molecular Formula | C24H19NO7S |
| Molecular Weight | 465.475 |
| Flash Point | 385.8±35.7 °C |
| Exact Mass | 465.088226 |
| PSA | 131.29000 |
| LogP | 3.55 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.676 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |
| Benzoic acid, 3-[[[3-[4-[(methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]- |
| 3-{[(3-{4-[(Methylsulfonyl)amino]phenyl}-4-oxo-4H-chromen-7-yl)oxy]methyl}benzoic acid |
| CVT-10216 |