CLK inhibitor T3
Modify Date: 2023-01-11 17:03:00
CLK inhibitor T3 structure
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Common Name | CLK inhibitor T3 | ||
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| CAS Number | 2109805-56-1 | Molecular Weight | 482.577 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C28H30N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CLK inhibitor T3CLK inhibitor T3 (T3) is a highly potent, selective, and cell-based stable CDC-like kinase (CLK) inhibitor with 0.67, 15 and 110 nM for CLK1,2 and 3, respectively; displays 200-300-fold selectivity over other dual specificity kinases such as DYRK1A and DYRK1B; induces dose-dependent reduction in exon recognition and exhibits an overlapping, but greater effect on transcriptome splicing compared to KH-CB19. |
| Name | 4-[2-Methyl-1-(4-methyl-1-piperazinyl)-1-oxo-2-propanyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide |
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| Synonym | More Synonyms |
| Description | CLK inhibitor T3 (T3) is a highly potent, selective, and cell-based stable CDC-like kinase (CLK) inhibitor with 0.67, 15 and 110 nM for CLK1,2 and 3, respectively; displays 200-300-fold selectivity over other dual specificity kinases such as DYRK1A and DYRK1B; induces dose-dependent reduction in exon recognition and exhibits an overlapping, but greater effect on transcriptome splicing compared to KH-CB19. |
|---|---|
| References | References 1. Funnell T, et al. Nat Commun. 2017 Feb 23;8(1):7. View Related Products by Target Cdc2-like Kinase (CLK) |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C28H30N6O2 |
| Molecular Weight | 482.577 |
| Exact Mass | 482.243011 |
| LogP | 2.36 |
| Index of Refraction | 1.659 |
| 4-[2-Methyl-1-(4-methyl-1-piperazinyl)-1-oxo-2-propanyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide |
| MFCD31689325 |
| Benzamide, 4-[1,1-dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]- |