2366264-18-6

2366264-18-6 structure

2366264-18-6 structure

Name: JNK3 inhibitor-2
Chemical Name: JNK3 inhibitor-2
CAS Number: 2366264-18-6
Molecular Formula: C₂₀H₁₄N₂O₂
Molecular Weight: 314.34
Catalog: Signaling Pathways MAPK/ERK Pathway JNK
Create Date: 2022-08-31 12:02:35
Modify Date: 2024-04-09 19:36:47
JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor with IC50 values of >100, >100, 0.25 µM for JNK1, JNK2, JNK3, respectively. JNK3 inhibitor-2 shows DDR1 and EGFR (T790M, L858R) inhibition[1].

Name	JNK3 inhibitor-2

Description	JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor with IC50 values of >100, >100, 0.25 µM for JNK1, JNK2, JNK3, respectively. JNK3 inhibitor-2 shows DDR1 and EGFR (T790M, L858R) inhibition[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> MAPK/ERK Pathway >> JNK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Discoidin Domain Receptor
Target	JNK1:>100 μM (IC50) JNK2:>100 μM (IC50) JNK3:0.25 μM (IC50)
In Vitro	JNK3 inhibitor-2 (compound J46) shows 30% and 60% inhibition to JNK2α2 at 30 μM and 100 μM, respectively[1]. JNK3 inhibitor-2 shows inhibitory ability for DDR1 and EGFR (T790M, L858R) with IC50s of 0.16, 0.37 µM, respectively[1].
References	[1]. Dou X, et al. Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors. Eur J Med Chem. 2020 Sep 1;201:112445.

Molecular Formula	C₂₀H₁₄N₂O₂
Molecular Weight	314.34