Curvularin
Curvularin structure
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Common Name | Curvularin | ||
|---|---|---|---|---|
| CAS Number | 10140-70-2 | Molecular Weight | 292.32700 | |
| Density | 1.2g/cm3 | Boiling Point | 557ºC at 760mmHg | |
| Molecular Formula | C16H20O5 | Melting Point | 205-207 °C | |
| MSDS | Chinese USA | Flash Point | 207.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Sulfur-containing cytotoxic curvularin macrolides from Penicillium sumatrense MA-92, a fungus obtained from the rhizosphere of the mangrove Lumnitzera racemosa.
J. Nat. Prod. 76(11) , 2145-9, (2013) Sumalarins A-C (1-3), the new and rare examples of sulfur-containing curvularin derivatives, along with three known analogues (4-6), were isolated and identified from the cytotoxic extract of Penicillium sumatrense MA-92, a fungus obtained from the rhizospher... |
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Metabolite production by differentUlocladiumspecies
Int. J. Food Microbiol. 126(1-2) , 172-9, (2008) Ulocladium, which is phylogenetically related to Alternaria, contains species that are food spoilers and plant pathogens, but also species that have potential as enzyme producers and bio-control agents. Ulocladium spp. are often found on dead vegetation, in s... |
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[Molecular basis of probes for cytoskeletal proteins].
Tanpakushitsu Kakusan Koso. 38(11) , 1730-41, (1993)
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[Functional and distributional changes of MTOC's in centrosomes induced by antimitotic agents].
Tanpakushitsu Kakusan Koso. 34(12 Suppl) , 1610-7, (1989)
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[Biological activity of Penicillium sp. 10-51 exometabolites].
Mikrobiol. Z. 74(4) , 52-6, (2012) Silica gel column chromatography (silica gel "L" II kind of activity 100/160 mkm) of the chloroform extract from the cultural filtrate of Penicillium sp. 10-51 gave two fractions (chloroform and chloroform-acetone, 5:1) having biological activity. Recrystalli... |
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Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes.
Biochem. Pharmacol. 79(5) , 722-32, (2010) Chondrocytes are important for the development and maintenance of articular cartilage. However, both in osteoarthritis (OA) and rheumatoid arthritis (RA) chondrocytes are involved in the process of cartilage degradation and synthesize important immunomodulato... |
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Aryne acyl-alkylation in the general and convergent synthesis of benzannulated macrolactone natural products: an enantioselective synthesis of (-)-curvularin.
Org. Lett. 12(7) , 1612-4, (2010) A general approach for the synthesis of benzannulated macrolactone natural products utilizing an aryne acyl-alkylation reaction is described. Toward this end, the total syntheses of the natural products (-)-curvularin, curvulin, and (-)-diplodialide C are rep... |
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Total synthesis of (s)-(+)-citreofuran by ring closing alkyne metathesis.
J. Org. Chem. 68(4) , 1521-8, (2003) A concise total synthesis of citreofuran 4 is described, a structurally unique octaketide derivative belonging to the curvularin family. Key steps involve the elaboration of orsellinic acid methyl ester 5 to acid 14, which converts, on attempted formation of ... |
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A concise synthetic approach to beta,gamma-dehydrocurvularin: synthesis of (+/-)-di-O-methyl-beta,gamma-dehydrocurvularin.
Biosci. Biotechnol. Biochem. 71(6) , 1592-4, (2007) A concise synthesis of di-O-methyl-beta,gamma-dehydrocurvularin, the di-O-methylated derivative of the naturally occurring nematicidal macrolide, beta,gamma-dehydrocurvuralin, was accomplished by starting from a commercially available aromatic carboxylic acid... |
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Microbial transformation of curvularin.
J. Nat. Prod. 68(8) , 1271-3, (2005) The microbiological transformation of curvularin (1) with Beauveria bassiana ATCC 7159 afforded three new metabolites identified as curvularin-7-O-beta-D-glucopyranoside (2), curvularin-4'-O-methyl-7-O-beta-D-glucopyranoside (3), and 6-hydroxycurvularin-4'-O-... |