Sitamaquine tosylate

Modify Date: 2024-01-07 09:24:36

Sitamaquine tosylate Structure
Sitamaquine tosylate structure
Common Name Sitamaquine tosylate
CAS Number 1019640-33-5 Molecular Weight 515.70800
Density N/A Boiling Point N/A
Molecular Formula C28H41N3O4S Melting Point N/A
MSDS USA Flash Point N/A

 Use of Sitamaquine tosylate


Sitamaquine (WR 6026) tosylate, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes[1].

 Names

Name N,N-Diethyl-N'-(6-methoxy-4-methyl-8-quinolinyl)-1,6-hexanediamin e 4-methylbenzenesulfonate (1:1)
Synonym More Synonyms

 Sitamaquine tosylate Biological Activity

Description Sitamaquine (WR 6026) tosylate, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes[1].
Related Catalog
References

[1]. López-Martín C, et al. Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes. Antimicrob Agents Chemother. 2008;52(11):4030-4036.

 Chemical & Physical Properties

Molecular Formula C28H41N3O4S
Molecular Weight 515.70800
Exact Mass 515.28200
PSA 100.14000
LogP 7.26140

 Safety Information

RIDADR NONH for all modes of transport

 Synonyms

Sitagliptin phosphate hydrate
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine dihydrogenphosphate monohydrate
Sitagliptin phosphate hydrate (jan)
Sitagliptin monohydrate
sitamaquine tosylate
3(R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H [1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one phosphate monohydrate
Sitagliptin phosphate (usan)
N,N-diethyl-N'-[4-methyl-6-(methyloxy)-8-quinolinyl]-1,6-hexanediamine tosylate
Januvia (tn)
Sitagliptin phosphate for research
7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)Butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazinephosphatemonohydrate
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