Alvelestat tosylate
Modify Date: 2024-01-05 19:59:14
Alvelestat tosylate structure
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Common Name | Alvelestat tosylate | ||
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| CAS Number | 1240425-05-1 | Molecular Weight | 717.73500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H30F3N5O7S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Alvelestat tosylateAlvelestat (tosylate) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC50 value of 7.9 nM, a Ki value of 9.4 nM and a Kd value of 9.5 nM[1]. |
| Name | 4-methylbenzenesulfonic acid,6-methyl-5-(2-methylpyrazol-3-yl)-N-[(5-methylsulfonylpyridin-2-yl)methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide |
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| Synonym | More Synonyms |
| Description | Alvelestat (tosylate) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC50 value of 7.9 nM, a Ki value of 9.4 nM and a Kd value of 9.5 nM[1]. |
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| Related Catalog | |
| Target |
pIC: 7.9 nM; Ki: 9.4 nM; Kd: 9.5 nM (neutrophil elastas)[1] |
| In Vitro | Alvelestat (20 μg/mL; 16 hours; HBE and A549 cells) treatment decreases cells death and decreases the levels of IL-1β, IL-6, and TNF-α in vitro[2]. |
| References |
| Molecular Formula | C32H30F3N5O7S2 |
|---|---|
| Molecular Weight | 717.73500 |
| Exact Mass | 717.15400 |
| PSA | 187.08000 |
| LogP | 7.08790 |
| UNII-E1B3T25UM9 |
| Alvelestat tosilate |
| Alvelestat tosylate |
| 3-Pyridinecarboxamide,1,2-dihydro-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)-2-pyridinyl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-,4-methylbenzenesulfonate (1:1) |
| AZD-9668 tosylate |