Alvelestat tosylate

Modify Date: 2024-01-05 19:59:14

Alvelestat tosylate structure	Common Name	Alvelestat tosylate
	CAS Number	1240425-05-1	Molecular Weight	717.73500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₃₀F₃N₅O₇S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Alvelestat tosylate

Alvelestat (tosylate) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC50 value of 7.9 nM, a Ki value of 9.4 nM and a Kd value of 9.5 nM[1].

Name	4-methylbenzenesulfonic acid,6-methyl-5-(2-methylpyrazol-3-yl)-N-[(5-methylsulfonylpyridin-2-yl)methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide
Synonym	More Synonyms

Description	Alvelestat (tosylate) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC50 value of 7.9 nM, a Ki value of 9.4 nM and a Kd value of 9.5 nM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase Research Areas >> Inflammation/Immunology
Target	pIC: 7.9 nM; Ki: 9.4 nM; Kd: 9.5 nM (neutrophil elastas)[1]
In Vitro	Alvelestat (20 μg/mL; 16 hours; HBE and A549 cells) treatment decreases cells death and decreases the levels of IL-1β, IL-6, and TNF-α in vitro[2].
References	[1]. Stevens T, et al. AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. J Pharmacol Exp Ther. 2011 Oct;339(1):313-20. [2]. Li H, et al. Neutrophil extracellular traps contribute to the pathogenesis of acid-aspiration-induced ALI/ARDS. Oncotarget. 2017 Nov 28;9(2):1772-1784.

Molecular Formula	C₃₂H₃₀F₃N₅O₇S₂
Molecular Weight	717.73500
Exact Mass	717.15400
PSA	187.08000
LogP	7.08790

UNII-E1B3T25UM9

Alvelestat tosilate

Alvelestat tosylate

3-Pyridinecarboxamide,1,2-dihydro-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)-2-pyridinyl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-,4-methylbenzenesulfonate (1:1)

AZD-9668 tosylate

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Alvelestat tosylate
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Alvelestat tosylate
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Alvelestat tosylate

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