ZM 39923 HCl
Modify Date: 2024-01-02 09:17:48
ZM 39923 HCl structure
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Common Name | ZM 39923 HCl | ||
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| CAS Number | 1021868-92-7 | Molecular Weight | 367.91 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H26ClNO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ZM 39923 HClZM39923 hydrochloride is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 hydrochloride also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM. |
| Name | N-benzyl-N-isopropyl-3-(2-naphthyl)but-3-en-1-amine,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | ZM39923 hydrochloride is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 hydrochloride also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM. |
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| Related Catalog | |
| Target |
JAK3:7.1 (pIC50) JAK1:4.4 (pIC50) EGF-R:5.6 (pIC50) Lck:5.0 (pIC50) CDK4:5.0 (pIC50) TGM2:10 nM (IC50) |
| In Vitro | ZM39923 hydrochloride is a JAK3 inhibitor, with a pIC50 of 7.1. ZM39923 (Compound 7) shows weak inhibitory effect on EGF-R and JAK1 (pIC50, 5.6, 4.4, respectively), and insignificantly inhibits tyrosine kinases Lck and CDK4 (pIC50 <5.0)[1]. ZM39923 potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM, and acts directly on purified TGM2 to inhibit the Ca2+ activated form of TGM2[2]. ZM39923 blocks the phosphorylation of JAK3 induced by CCL19, and such an effect is similar to that of CCR7 antibody. ZM39923 also significantly blocks the CCL19 induced wound closure rate, and decreases the migration and invasion of PCI-37B cells[3]. |
| Cell Assay | PCI-37B (a metastatic SCCHN cell line expressing CCR7) cells are cultured in Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal bovine serum, penicillin, and streptomycin in an atmosphere of 5% CO2 and 95% air at 37°C. The ZM39923 inhibitor treatment at the dose determined using the Cell Counting Kit-8[3]. |
| References |
| Molecular Formula | C23H26ClNO |
|---|---|
| Molecular Weight | 367.91 |
| PSA | 3.24000 |
| LogP | 6.95570 |
| Storage condition | -20°C |
| 2-Naphthalenepropanamine, γ-methylene-N-(1-methylethyl)-N-(phenylmethyl)-, hydrochloride (1:1) |
| N-Benzyl-N-isopropyl-3-(2-naphthyl)-3-buten-1-amine hydrochloride (1:1) |
| 3-[(1-Methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-1-propanone hydrochloride |
| ZM 39923 hydrochloride |
| ZM39923 (hydrochloride) |