Difelikefalin (CR845)

Modify Date: 2024-01-09 23:20:02

Difelikefalin (CR845) structure	Common Name	Difelikefalin (CR845)
	CAS Number	1024828-77-0	Molecular Weight	679.84900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₆H₅₃N₇O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Difelikefalin (CR845)

Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease[1][2].

Name	Difelikefalin
Synonym	More Synonyms

Description	Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	kappa opioid receptor (KOR)[1]
In Vitro	Difelikefalin (CR-845; FE-202845) does not penetrate the blood-brain barrier. Difelikefalin does not bind to mu opioid receptors or any other receptors beside KORs[1].
References	[1]. Steven Fishbane, et al. Randomized Controlled Trial of Difelikefalin for Chronic Pruritus in Hemodialysis Patients. Kidney Int Rep. 2020 Jan 28;5(5):600-610. [2]. Steven Fishbane, et al. A Phase 3 Trial of Difelikefalin in Hemodialysis Patients With Pruritus. N Engl J Med. 2020 Jan 16;382(3):222-232.

Molecular Formula	C₃₆H₅₃N₇O₆
Molecular Weight	679.84900
Exact Mass	679.40600
PSA	222.97000
LogP	4.04460

CR845

FE-202845

D-Phe-D-Phe-D-Leu-D-Lys-[γ-(4-N-piperidinyl)amino carboxylic acid]

4-Piperidinecarboxylic acid, N1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-amino-

N1-(D-Phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-amino-4-piperidinecarboxylic acid

1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid

DC Chemicals Limited
China
Product Name: Difelikefalin (CR845)
Price: $600.0/10mg $900.0/25mg $1600.0/50mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Difelikefalin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Taiwan Oyi peptide Co. Ltd
China
Product Name: Difelikefalin (CR845)
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Vinnie

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Difelikefalin (CR845)

Use of Difelikefalin (CR845)

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Difelikefalin (CR845) Biological Activity

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