MMP145

Modify Date: 2024-02-19 13:41:37

Use of MMP145

MMP145 (compound 27) is a potent, selective and orally active MMP-12 inhibitor. MMP145 is effective in inflammation and asthma reasearch[1].

Name	N-{[8-(2-Oxo-1,3-oxazolidin-3-yl)dibenzo[b,d]furan-3-yl]sulfonyl} -L-valine

Description	MMP145 (compound 27) is a potent, selective and orally active MMP-12 inhibitor. MMP145 is effective in inflammation and asthma reasearch[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
References	[1]. Wei Li,Jianchang Li,Yuchuan Wu,Fabio Rancati,Stefania Vallese,Luca Raveglia ,Junjun Wu ,Rajeev Hotchandani,Nathan Fuller,Kristina Cunningham ,Paul Morgan ,Susan Fish,Rustem Krykbaev , Xin Xu , Steve Tam , Samuel J. Goldman , William Abraham , Cara Williams,Joseph Sypek and Tarek S.Mansour.Identification of an Orally Efficacious Matrix Metalloprotease 12 Inhibitor for Potential Treatment of AsthmaJ. Med. Chem., 2009, 52 (17), pp 5408–5419. [2]. Li W, et, al. Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma. J Med Chem. 2009 Sep 10;52(17):5408-19.

Description

MMP145 (compound 27) is a potent, selective and orally active MMP-12 inhibitor. MMP145 is effective in inflammation and asthma reasearch[1].

Related Catalog

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

References