4-Benzyloxyphenol

Modify Date: 2026-07-12 11:12:01

4-Benzyloxyphenol structure	Common Name	4-Benzyloxyphenol
	CAS Number	103-16-2	Molecular Weight	200.233
	Density	1.2±0.1 g/cm3	Boiling Point	359.1±17.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₁₂O₂	Melting Point	119-120 °C(lit.)
	MSDS	Chinese USA	Flash Point	213.4±5.9 °C
	Symbol	GHS07	Signal Word	Warning

Use of 4-Benzyloxyphenol

Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and active human vitiligo and exhibits good potential for vitiligo research[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	monobenzone
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and active human vitiligo and exhibits good potential for vitiligo research[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Zhu Y, et al. A mouse model of vitiligo induced by monobenzone. Exp Dermatol. 2013 Jul;22(7):499-501. doi: 10.1111/exd.12184.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.2±0.1 g/cm3
Boiling Point	359.1±17.0 °C at 760 mmHg
Melting Point	119-120 °C(lit.)
Molecular Formula	C₁₃H₁₂O₂
Molecular Weight	200.233
Flash Point	213.4±5.9 °C
Exact Mass	200.083725
PSA	29.46000
LogP	2.96
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.603
InChIKey	VYQNWZOUAUKGHI-UHFFFAOYSA-N
SMILES	Oc1ccc(OCc2ccccc2)cc1
Water Solubility	slightly soluble

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

4-Benzyloxyphenol MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SJ7700000

CHEMICAL NAME :: Phenol, p-(benzyloxy)-

CAS REGISTRY NUMBER :: 103-16-2

BEILSTEIN REFERENCE NO. :: 1958305

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C13-H12-O2

MOLECULAR WEIGHT :: 200.25

WISWESSER LINE NOTATION :: QR DO1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 28,357,1977 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,983,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year: 3,93,1976 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 163 gm/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4903 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 367 (estimated) No. of Female Employees: 16 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317-H319
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36;R43
Safety Phrases	S24/25-S26-S37
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	SJ7700000
Packaging Group	I; II; III
HS Code	29095090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 8
CAS#:200956-20-3 1-phenylmethoxy... CAS#:100-39-0 Benzyl bromide CAS#:123-31-9 Hydroquinone CAS#:106-51-4 1,4-Benzoquinone
CAS#:100-51-6 Benzyl alcohol CAS#:146631-00-7 (4-(Benzyloxy)p... CAS#:50635-26-2 [4-(Benzyloxy)p... CAS#:6311-66-6 4-Benzyloxyphen...
DownStream 10
CAS#:108154-93-4 12-(4-phenylmet... CAS#:3780-50-5 4-(Octyloxy)phenol CAS#:3351-59-5 1-(BENZYLOXY)-4... CAS#:3233-32-7 4-Acetoxyphenol
CAS#:38559-92-1 [4-(Benzyloxy)p... CAS#:143389-15-5 4-[2-tert-butyl... CAS#:142717-44-0 ethyl 2-(4-phen... CAS#:142627-91-6 4-(6-Hydroxyhex...
CAS#:18110-26-4 2-[(4-ethoxyphe... CAS#:2150-58-5 phenol blue

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2909500000
Summary	2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

J. Med. Chem. 48 , 5666-74, (2005)

We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular d...

Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin.

Arch. Biochem. Biophys. 563 , 71-8, (2014)

Monobenzyl ether of hydroquinone (MBEH) is cytotoxic towards melanocytes. Its treatment efficacy is limited by an inability to eradicate stem cells. By contrast, 8-hydroxy-N,N-dipropyl-2-aminotetralin...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-keats_OPM1-m4-1

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-OC1MY5-m4-1

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-KMS_34-m4-1

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-keats_L363-m4-1

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-keats_OCIMY7-m4-1

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-MM1R-m4-1

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-mm1s-m4-1

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-KMS-28PE-m4-1

Total 547, Current Page 1 of 55

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

4-Benzyloxyphenol

4-(Benzyloxy)phenol

agerite

Hydroquinone Monobenzyl Ether

EINECS 203-083-3

4-benzyloxy phenol

4-(Benzyloxy)benzolol

4-(Benzyloxyl)phenol

Benzyl hydroquinone

MFCD00002333

PBP

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the boiling point of monobenzone?

A: Boiling point of monobenzone is 359.1±17.0 °C at 760 mmHg.

Q: What are the upstream materials of monobenzone?

A: Related upstream materials(CAS) of monobenzone: 200956-20-3;100-39-0;123-31-9;106-51-4;100-51-6;146631-00-7;50635-26-2;6311-66-6.

Q: What English synonyms does monobenzone have?

A: English synonyms of monobenzone: 4-Benzyloxyphenol, 4-(Benzyloxy)phenol, agerite, Hydroquinone Monobenzyl Ether, EINECS 203-083-3, 4-benzyloxy phenol, 4-(Benzyloxy)benzolol, 4-(Benzyloxyl)phenol, Benzyl hydroquinone, MFCD00002333, PBP.

Q: What is the molecular weight of monobenzone?

A: Molecular weight of monobenzone is 200.233.

Q: What is the melting point of monobenzone?

A: Melting point of monobenzone is 119-120 °C(lit.).

Q: What is the molecular formula of monobenzone?

A: Molecular formula of monobenzone is C13H12O2.

Q: What are the downstream products of monobenzone?

A: Related downstream products(CAS) of monobenzone: 108154-93-4;3780-50-5;3351-59-5;3233-32-7;38559-92-1;143389-15-5;142717-44-0;142627-91-6;18110-26-4;2150-58-5.

Q: What is the CAS number of monobenzone?

A: CAS number of monobenzone is 103-16-2.

Q: What are the uses of monobenzone?

A: Main uses of monobenzone: Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and active human vitiligo and exhibits good potential for vitiligo research[1].

Q: What is the English name of monobenzone?

A: The English name of monobenzone is monobenzone.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-Benzyloxyphenol
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Benzyloxyphenol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Monobenzone
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 4-Benzyloxyphenol
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

Get all suppliers and price by the below link:

4-Benzyloxyphenol suppliers

Price: ￥78/10g

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4-Benzyloxyphenol

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