JTV-519 hydrochloride
Modify Date: 2024-04-10 19:19:41
JTV-519 hydrochloride structure
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Common Name | JTV-519 hydrochloride | ||
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| CAS Number | 1038410-88-6 | Molecular Weight | 461.06 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H33ClN2O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JTV-519 hydrochlorideJTV-519 (K201) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties[1][2]. |
| Name | 3-(4-benzylpiperidin-1-yl)-1-(7-methoxy-3,5-dihydro-2H-1,4-benzothiazepin-4-yl)propan-1-one,hydrochloride |
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| Synonym | More Synonyms |
| Description | JTV-519 (K201) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties[1][2]. |
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| Related Catalog | |
| In Vitro | JTV-519 (K201) 以剂量依赖的方式抑制由膜联蛋白 V 引起的 Ca2+ 向内移动到大单层囊泡 (LUV)。在 50 nM 膜联蛋白 V 和 400 μM Ca2+ 存在的情况下，3 μM JTV-519 对 Ca2+ 的抑制作用显著，25 μM K201 的抑制作用达到 50%[2]。 |
| In Vivo | JTV-519 (0.5mg/kg/h，术前 2 h 静脉注射) 可改善 CLP 小鼠的心功能，其中与未经 JTV-519 处理的 CLP 小鼠相比，分数缩短 (FS) 和射血分数 (EF) 显著增加[3]。 Animal Model: Wild type male C57BL/6 mice weighing 18-22g with polymicrobial sepsis produced by cecal ligation and puncture (CLP) [3] Dosage: 0.5 mg/kg/h Administration: Applied intraperitoneally 2 h before the surgery Result: Improved cardiac function, where the EF and FS were significantly increased. |
| References |
| Molecular Formula | C25H33ClN2O2S |
|---|---|
| Molecular Weight | 461.06 |
| Exact Mass | 460.19500 |
| PSA | 58.08000 |
| LogP | 5.15210 |
| k201 |
| jtv 519 |
| unii-0i621y6r4q |