PF-03654746 Tosylate

Modify Date: 2024-01-06 16:55:24

PF-03654746 Tosylate structure	Common Name	PF-03654746 Tosylate
	CAS Number	1039399-17-1	Molecular Weight	494.59400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₃₂F₂N₂O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PF-03654746 Tosylate

PF-03654746 Tosylate is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 Tosylate reduces allergen-induced nasal symptoms[1]. PF-03654746 Tosylate has potential for treatment of human cognitive disorders, improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD)[2].

Name	N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane-1-carboxamide,4-methylbenzenesulfonic acid
Synonym	More Synonyms

Description	PF-03654746 Tosylate is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 Tosylate reduces allergen-induced nasal symptoms[1]. PF-03654746 Tosylate has potential for treatment of human cognitive disorders, improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD)[2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H3 receptor[1]
References	[1]. Stokes JR, et al. The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2. [2]. Brioni JD, et al. Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46.

Molecular Formula	C₂₅H₃₂F₂N₂O₄S
Molecular Weight	494.59400
Exact Mass	494.20500
PSA	98.58000
LogP	6.23310

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PF-03654746 Tosylate
Price: Negotiable
Purity: 99.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: PF 3654746
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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PF-03654746 Tosylate

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