IRAK inhibitor 1
Modify Date: 2024-01-02 12:08:12
IRAK inhibitor 1 structure
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Common Name | IRAK inhibitor 1 | ||
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| CAS Number | 1042224-63-4 | Molecular Weight | 293.36600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H19N5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IRAK inhibitor 1IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively. |
| Name | 6-imidazo[1,2-a]pyridin-3-yl-N-piperidin-4-ylpyridin-2-amine |
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| Synonym | More Synonyms |
| Description | IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively. |
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| Related Catalog | |
| Target |
IC50: 216 nM (IRAK-4), 3.801 μM (JNK-1), >10 μM (JNK-2)[1] |
| In Vitro | IRAK inhibitor 1 possesses significant potency in an IRAK-4 enzyme assay but is poorly active against JNK-1 and JNK-2[1]. IRAK-4 is a novel member of the IRAK family with unique functional properties. IRAK-4 is the closest human homolog to Pelle. Endogenous IRAK-4 interacts with IRAK-1 and TRAF6 in an IL-1-dependent manner, and overexpression of IRAK-4 can activate NF-κB as well as mitogen-activated protein (MAP) kinase pathways. Most strikingly, and in contrast to the other IRAKs, IRAK-4 depends on its kinase activity to activate NF-κB. In addition, IRAK-4 is able to phosphorylate IRAK-1, and overexpression of dominant-negative IRAK-4 is blocking the IL-1-induced activation and modification of IRAK-1, suggesting a role of IRAK-4 as a central element in the early signal transduction of Toll/IL-1 receptors, upstream of IRAK-1. IRAK-4 shares the domain structure of the other IRAKs and it is able to activate similar signal transduction pathways, namely NF-κB and MAPK pathways. It rapidly and transiently associates with IRAK-1 and TRAF6 in an IL-1-dependent manner but it is not functionally redundant with IRAK-1. IRAK-4 is an active protein kinase and requires its kinase activity to activate NF-κB. IRAK-4 might act upstream of IRAK-1 as an IRAK-1 activator[2]. |
| References |
| Molecular Formula | C17H19N5 |
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| Molecular Weight | 293.36600 |
| Exact Mass | 293.16400 |
| PSA | 54.25000 |
| LogP | 2.96200 |
| Storage condition | 2-8℃ |
| CS-0603 |
| IRAK inhibitor 1 |