VPS34 inhibitor 1 (Compound 19, PIK-III analogue)

Modify Date: 2024-01-14 10:01:11

VPS34 inhibitor 1 (Compound 19, PIK-III analogue) Structure
VPS34 inhibitor 1 (Compound 19, PIK-III analogue) structure
Common Name VPS34 inhibitor 1 (Compound 19, PIK-III analogue)
CAS Number 1383716-46-8 Molecular Weight 391.47
Density 1.3±0.1 g/cm3 Boiling Point 676.1±65.0 °C at 760 mmHg
Molecular Formula C21H25N7O Melting Point N/A
MSDS N/A Flash Point 362.7±34.3 °C

 Use of VPS34 inhibitor 1 (Compound 19, PIK-III analogue)


Vps34-IN-4 (compound 19) is a potent, selective, and orally active inhibitor of VPS34. Vps34-IN-4 inhibits the autophagy in vivo. Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components[1].

 Names

Name Vps
Synonym More Synonyms

  Biological Activity

Description Vps34-IN-4 (compound 19) is a potent, selective, and orally active inhibitor of VPS34. Vps34-IN-4 inhibits the autophagy in vivo. Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components[1].
Related Catalog
References

[1]. Honda A, et al. Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo. ACS Med Chem Lett. 2015;7(1):72-76.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 676.1±65.0 °C at 760 mmHg
Molecular Formula C21H25N7O
Molecular Weight 391.47
Flash Point 362.7±34.3 °C
Exact Mass 391.212067
LogP 2.59
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.686
Storage condition -20℃

 Synonyms

VPS34
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