GppCp(GMPPCP)

Modify Date: 2024-01-04 02:50:18

GppCp(GMPPCP) Structure
GppCp(GMPPCP) structure
Common Name GppCp(GMPPCP)
CAS Number 10470-57-2 Molecular Weight 587.15
Density N/A Boiling Point N/A
Molecular Formula C11H15N5Na3O13P3 Melting Point N/A
MSDS USA Flash Point N/A

 Use of GppCp(GMPPCP)


5′-Guanylyl methylenediphosphonate (sodium) is a GTP analogue and a specific, competitive inhibitor of the GTP reaction in protein synthesis[1].

 Names

Name trisodium guanosine 5'-[β,γ-methylene]triphosphate
Synonym More Synonyms

 GppCp(GMPPCP) Biological Activity

Description 5′-Guanylyl methylenediphosphonate (sodium) is a GTP analogue and a specific, competitive inhibitor of the GTP reaction in protein synthesis[1].
Related Catalog
References

[1]. Hershey JW, et.al. A competitive inhibitor of the GTP reaction in protein synthesis. J Mol Biol. 1966 Jun;18(1):68-76.  

 Chemical & Physical Properties

Molecular Formula C11H15N5Na3O13P3
Molecular Weight 587.15
Exact Mass 544.00100
PSA 320.29000

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport

 Articles11

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Polarized endosome dynamics by spindle asymmetry during asymmetric cell division.

Nature 528 , 280-5, (2015)

During asymmetric division, fate determinants at the cell cortex segregate unequally into the two daughter cells. It has recently been shown that Sara (Smad anchor for receptor activation) signalling ...

Dynamic and thermodynamic response of the Ras protein Cdc42Hs upon association with the effector domain of PAK3.

J. Mol. Biol. 426(21) , 3520-38, (2014)

Human cell division cycle protein 42 (Cdc42Hs) is a small, Rho-type guanosine triphosphatase involved in multiple cellular processes through its interactions with downstream effectors. The binding dom...

Regulation of human tissue transglutaminase function by magnesium-nucleotide complexes. Identification of distinct binding sites for Mg-GTP and Mg-ATP.

J. Biol. Chem. 273 , 1776-1781, (1998)

Tissue transglutaminase (tTG) catalyzes a Ca(2+)-dependent transglutaminase (TGase) activity that stabilizes tissues and a GTP hydrolysis activity that regulates cell receptor signaling. The purpose o...

 Synonyms

GMPPCP
[[[5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]methylphosphonic acid,sodium
trisodium guanosine 5'-[beta,gamma-methylene]triphosphate
GppCp
|A,|A-Methyleneguanosine 5 inverted exclamation marka-triphosphate sodium salt
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