MF-438

Modify Date: 2024-04-13 17:09:10

MF-438 Structure
MF-438 structure
Common Name MF-438
CAS Number 921605-87-0 Molecular Weight 421.44
Density N/A Boiling Point N/A
Molecular Formula C19H18F3N5OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MF-438


MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an EC50 of 2.3 nM for rSCD1[1].

 Names

Name MF-438

 MF-438 Biological Activity

Description MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an EC50 of 2.3 nM for rSCD1[1].
Related Catalog
Target

EC50: 2.3 nM (rSCD1)[1]

In Vivo MF-438 exhibits an ED50 between 1 and 3 mg/kg in a mouse model[1].
References

[1]. Léger S, et al. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502.

 Chemical & Physical Properties

Molecular Formula C19H18F3N5OS
Molecular Weight 421.44
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