Rufinamide

Modify Date: 2024-01-01 20:15:47

Rufinamide structure	Common Name	Rufinamide
	CAS Number	106308-44-5	Molecular Weight	238.193
	Density	1.5±0.1 g/cm3	Boiling Point	473.8±55.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₈F₂N₄O	Melting Point	232-234?C
	MSDS	Chinese USA	Flash Point	240.4±31.5 °C

Use of Rufinamide

Rufinamide(E 2080; CGP 33101; RUF 331) is a new antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).IC50 Value:Target: in vitro:in vivo: Rufinamide and amitriptyline alleviated injury-induced mechanical allodynia for 4 h (maximal effect: 0.10 ± 0.03 g (mean ± SD) to 1.99 ± 0.26 g for rufinamide and 0.25 ± 0.22 g to 1.92 ± 0.85 g for amitriptyline) in mice [1]. Oral rufinamide suppressed pentylenetetrazol-induced seizures in mice (ED(50) 45.8 mg/kg) but not rats, and was active against MES-induced tonic seizures in mice (ED(50) 23.9 mg/kg) and rats (ED(50) 6.1 mg/kg) [2]. Intraperitoneal rufinamide suppressed pentylenetetrazol-, bicuculline-, and picrotoxin-induced clonus in mice (ED(50) 54.0, 50.5, and 76.3 mg/kg, respectively).Clinical trial: Exploratory Study to Evaluate the Effect of SYN-111 (Rufinamide) in Patients With Generalized Anxiety Disorder (GAD). Phase 2

Name	Rufinamide
Synonym	More Synonyms

Description	Rufinamide(E 2080; CGP 33101; RUF 331) is a new antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).IC50 Value:Target: in vitro:in vivo: Rufinamide and amitriptyline alleviated injury-induced mechanical allodynia for 4 h (maximal effect: 0.10 ± 0.03 g (mean ± SD) to 1.99 ± 0.26 g for rufinamide and 0.25 ± 0.22 g to 1.92 ± 0.85 g for amitriptyline) in mice [1]. Oral rufinamide suppressed pentylenetetrazol-induced seizures in mice (ED(50) 45.8 mg/kg) but not rats, and was active against MES-induced tonic seizures in mice (ED(50) 23.9 mg/kg) and rats (ED(50) 6.1 mg/kg) [2]. Intraperitoneal rufinamide suppressed pentylenetetrazol-, bicuculline-, and picrotoxin-induced clonus in mice (ED(50) 54.0, 50.5, and 76.3 mg/kg, respectively).Clinical trial: Exploratory Study to Evaluate the Effect of SYN-111 (Rufinamide) in Patients With Generalized Anxiety Disorder (GAD). Phase 2
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Neurological Disease
References	[1]. Suter MR, Kirschmann G, Laedermann CJ, Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology. 2013 Jan;118(1):160-72. [2]. White HS, Franklin MR, Kupferberg HJ, The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia. 2008 Jul;49(7):1213-20.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Natural Products >> Alkaloid

Research Areas >> Neurological Disease

References

[1]. Suter MR, Kirschmann G, Laedermann CJ, Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology. 2013 Jan;118(1):160-72.

[2]. White HS, Franklin MR, Kupferberg HJ, The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia. 2008 Jul;49(7):1213-20.

Density	1.5±0.1 g/cm3
Boiling Point	473.8±55.0 °C at 760 mmHg
Melting Point	232-234?C
Molecular Formula	C₁₀H₈F₂N₄O
Molecular Weight	238.193
Flash Point	240.4±31.5 °C
Exact Mass	238.066620
PSA	73.80000
LogP	0.05
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.635
Storage condition	−20°C
Water Solubility	DMSO: soluble9mg/mL

Rufinamide MSDS(Chinese)

Hazard Codes	F,T
Risk Phrases	11-23/24/25-39/23/24/25-48-41-38-28
Safety Phrases	7-16-36/37-45-36/37/39-28-26-24/25
RIDADR	UN 1648 3 / PGII

Dose-dependent pharmacokinetics and brain penetration of rufinamide following intravenous and oral administration to rats.

Eur. J. Pharm. Sci. 68 , 106-13, (2015)

Rufinamide is a third-generation antiepileptic drug, approved recently as an orphan drug for the treatment of Lennox-Gastaut syndrome. Although extensive research was conducted, its pharmacokinetics i...

Toxicological screening of human plasma by on-line SPE-HPLC-DAD: identification and quantification of basic drugs and metabolites.

Biomed. Chromatogr. 29 , 935-52, (2015)

An automated multi-analyte screening method for the identification and quantification of 92 drugs and metabolites based on on-line solid-phase extraction-high-performance liquid chromatography-diode a...

Rufinamide for the treatment of Lennox-Gastaut syndrome.

Expert Opin. Pharmacother. 12(5) , 801-6, (2011)

Lennox-Gastaut syndrome (LGS) is a severe treatment-resistant childhood-onset epilepsy. This review examines the role of the new drug rufinamide for the treatment of LGS.MEDLINE and Google Scholar sea...

1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-Triazole-4-carboxamide

1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide

Rufinamide

1H-1,2,3-Triazole-4-carboxamide, 1-[(2,6-difluorophenyl)methyl]-

1-((2,6-Difluorophenyl)methyl)-1H-1,2,3-triazole-4-carboxamide

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DC Chemicals Limited
China
Product Name: Rufinamide
Price: $300.0/100mg $600.0/250mg $1200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Rufinamide
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU CHEM- Rufinamide
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: $79/10mM*1mLinDMSO

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Rufinamide

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