Dafadine-A

Modify Date: 2024-01-11 06:32:17

Dafadine-A Structure
Dafadine-A structure
Common Name Dafadine-A
CAS Number 1065506-69-5 Molecular Weight 391.463
Density 1.2±0.1 g/cm3 Boiling Point 600.3±55.0 °C at 760 mmHg
Molecular Formula C23H25N3O3 Melting Point N/A
MSDS USA Flash Point 316.9±31.5 °C

 Use of Dafadine-A


Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1). IC50 value:Target: DAF-9(CYP27A1) inhibitorThe DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematodeCaenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals.

 Names

Name Dafadine-A
Synonym More Synonyms

 Dafadine-A Biological Activity

Description Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1). IC50 value:Target: DAF-9(CYP27A1) inhibitorThe DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematodeCaenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals.
Related Catalog
References

[1]. Luciani GM, et al. Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Nat Chem Biol. 2011 Nov 6;7(12):891-3.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 600.3±55.0 °C at 760 mmHg
Molecular Formula C23H25N3O3
Molecular Weight 391.463
Flash Point 316.9±31.5 °C
Exact Mass 391.189606
LogP 1.84
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.592
Storage condition 2-8℃

 Safety Information

RIDADR NONH for all modes of transport

 Synonyms

Dafadine A
Methanone, [5-[(2,6-dimethylphenoxy)methyl]-3-isoxazolyl][4-(4-pyridinyl)-1-piperidinyl]-
Dafadine-A
MFCD13125955
{5-[(2,6-Dimethylphenoxy)methyl]-1,2-oxazol-3-yl}[4-(4-pyridinyl)-1-piperidinyl]methanone
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